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In this study, we have uncovered novel proteolytic processing of the histone H3 tail in senescence models in primary fibroblasts and melanocytes. Cleavage of H3 tail occurs at two distinct residues and is mediated by Cathepsin L. We show that variant H3.3 is preferentially cleaved, and that cleaved ...
ORGANISM(S): Homo sapiens 
Math2 (NEX-1/NeuroD6) is a member of the bHLH transcription factor family and is involved in neuronal differentiation and maturation. In the present study, we identified the genes targeted by Math2 using DNA microarrays and cultured rat cortical cells transfected with Math2. Of the genes regulated b...
ORGANISM(S): Rattus norvegicus 
Twist1 induces cancer metastasis. Identification of Twist1 downstream targets should help to delineate the mechanisms of Twist1-induced cancer metastasis. Expression profiles of H1299 control cells vs. H1299 with knockdown of Twist1 were compared to identify Twist1 downstream targets.
ORGANISM(S): Homo sapiens 
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