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TranscriptomicsTranscription profiling of Arabidopsis treated with silwet for varying time and high throughout haplotyping and single feature polymorphism markers in Arabidopsis
The study of natural genetic variation for plant disease resistance responses is a complementary approach to utilizing mutants to elucidate genetic pathways. While some key genes involved in pathways controlling disease resistance, and signaling intermediates such as salicylic acid (SA) and jasmoni...
ORGANISM(S): Arabidopsis thaliana 
2006-11-14 | E-TABM-60 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis treated with silwet for varying time and high throughout haplotyping and single feature polymorphism markers in Arabidopsis
The study of natural genetic variation for plant disease resistance responses is a complementary approach to utilizing mutants to elucidate genetic pathways. While some key genes involved in pathways controlling disease resistance, and signaling intermediates such as salicylic acid (SA) and jasmoni...
ORGANISM(S): Arabidopsis thaliana 
2007-01-01 | E-TABM-61 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 148 Arabidopsis recombinant inbred lines treated with Silwet solution to develop genetic markers and derive high-density haplotypes
The study of natural genetic variation for plant disease resistance responses is a complementary approach to utilizing mutants to elucidate genetic pathways. While some key genes involved in pathways controlling disease resistance, and signaling intermediates such as salicylic acid (SA) and jasmoni...
ORGANISM(S): Arabidopsis thaliana 
2007-01-10 | E-TABM-62 | biostudies-arrayexpress
ProteomicsCancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC
The FBXW7 tumour suppressor is commonly mutated, deleted or hypermethylated in a variety of cancer histologies. The tumour suppressive role of the FBXW7 protein has been ascribed to its ability to drive the ubiquitination and degradation of oncoproteins via its role as a substrate recognition subuni...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043904 | Pride
Cdc Fbxw7 Synthetic lethal 
TranscriptomicsDistinctive profiles of small RNA couple inverted repeat-induced post-transcriptional gene silencing with endogenous RNA silencing pathways in Arabidopsis
Next-generation Illumina sequencing technology was used to analyze small RNA associated with post-transcriptional gene silencing induced by intron-spliced hairpin RNA (ihpRNA) in Arabidopsis. The experimental induction of RNA silencing in plants often involves expression of transgenes encoding inve...
ORGANISM(S): Arabidopsis thaliana 
2012-06-26 | E-GEOD-38922 | biostudies-arrayexpress
UnknownCancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.
Not available
S-EPMC10850818 | biostudies-literature
ProteomicsTargeting the CDS1/2 axis as a therapeutic strategy in uveal melanoma and pan-cancer
Metastatic uveal melanoma is an aggressive disease with limited effective therapeutic options. To comprehensively map monogenic and digenic dependencies, we performed CRISPR-Cas9 screening in ten extensively profiled human uveal melanoma cell line models using genome-wide single gene/gRNA and combin...
ORGANISM(S): Homo sapiens (Human) 
2025-04-01 | PXD053752 | Pride
Cds1 Cds2 Uveal melanom 
UnknownThe synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types.
Not available
S-EPMC12283370 | biostudies-literature
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