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ProteomicsKRAB Zincfinger Interactome - The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification
Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) represent the largest family of human transcription factors. The majority of its members bind to Transposable Elements (TEs), which they repress through the recruitment of the repressor KAP1 to their conserved KRAB domain. In addi...
ORGANISM(S): Homo sapiens (Human) 
2019-06-04 | PXD011322 | Pride
Zincfinger Ap-ms Mass spectrometry Krab 
ProteomicsProteomic analysis Carcinoma associated fibroblasts (CAFs) following genetic manipulation of NID2 expression
Proteomic anlaysis was performed on CAF GFP-1 KRAB, CAF B500 NID2 KRAB and CAF C500 NID2 KRAB cell lines
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050045 | Pride
Carcinoma associated fibroblasts Nid2 
GenomicsGenomic targets of the KRAB and scan domain-containing zinc finger protein 263 (ZNF263).
Half of all human transcription factors use C2H2 zinc finger domains to specify site-specific DNA binding and yet very little is known about their role in gene regulation. Based on in vitro studies, a zinc finger code has been developed that predicts a binding motif for a particular zinc finger fact...
ORGANISM(S): Homo sapiens 
2009-12-03 | E-GEOD-19235 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analysis of KAP1 Binding Suggests Auto-regulation of KRAB-ZNFs
We performed a genome-scale ChIP-chip comparison of two modifications (trimethylation of lysine 9 and trimethylation of lysine 27) of histone H3 in Ntera2 testicular carcinoma cells and in three different anatomical sources of primary human fibroblasts. We found that in each of the cell types the tw...
ORGANISM(S): Homo sapiens 
2007-09-29 | E-GEOD-8667 | biostudies-arrayexpress
GenomicsTransposable elements and their KRAB-ZFP controllers regulate gene expression in adult tissues
The tetrapod-restricted KRAB-containing zinc finger proteins (KRAB-ZFPs) are essential early embryonic controllers of transposable elements (TEs), which they repress via their cofactor KAP1 and associated effectors through histone and DNA methylation, a process thought to result in irreversible sile...
ORGANISM(S): Mus musculus 
2016-03-15 | E-GEOD-74278 | biostudies-arrayexpress
ProteomicsDownregulation of KRAB zinc finger proteins in 5-fluorouracil resistant colorectal cancer cells
The radio-chemotherapy with 5-fluorouracil (5-FU) is the standard of care treatment for patients with locally advanced rectal cancer (LARC) but it is only effective for a third of them. The proteomic and transcriptomic response of three colorectal cancer (CRC) cell lines to 5-FU and radiation was as...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD020000 | Pride
Colorectal cancer Tmt Protoemics 5-fu Chemoresistance 
UnknownZinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins.
Not available
S-EPMC3960175 | biostudies-literature
GenomicsGenome-wide binding patterns of murine KRAB zinc finger proteins
Genome-wide binding patterns of murine KRAB zinc finger proteins
PRJNA474488 | ENA
UnknownThe KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.
Not available
S-EPMC8835667 | biostudies-literature
GenomicsGenome-wide maps of chromatin state and KAP1 occupancy in KRAB zinc finger protein (KRAB-ZFP) gene cluster KO ES cells and testis
Genome-wide maps of chromatin state and KAP1 occupancy in KRAB zinc finger protein (KRAB-ZFP) gene cluster KO ES cells and testis
PRJNA474489 | ENA
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