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TranscriptomicsAnalysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/M-bM-^@M-^SK5-Cre and Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17345 | biostudies-arrayexpress
TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
UnknownTranscriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation.
Not available
S-EPMC3920956 | biostudies-literature
UnknownNF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression.
Not available
S-EPMC6404571 | biostudies-literature
TranscriptomicsThe activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65 I
The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-M-NM-:B subunit p65 in relation to active enhancers a...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64201 | biostudies-arrayexpress
TranscriptomicsThe activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65 II
The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-M-NM-:B subunit p65 in relation to active enhancers a...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64237 | biostudies-arrayexpress
TranscriptomicsAbsolute and induction TNF tolerance in primary human monocytes
The molecular basis of TNF tolerance is poorly understood. In this experiment, primary human monocytes were used to examine TNF refractoriness. We detect absolute tolerance as selective, dose-dependently affecting a small group of powerful effector molecules; induction tolerance represented a more ...
ORGANISM(S): Homo sapiens 
2014-02-11 | E-GEOD-45371 | biostudies-arrayexpress
ProteomicsDynamic proximity based interactome of the transcription factor RELA to identify gene-regulatory networks revealed
Using p65-miniTurbo fusion proteins in HeLa cells, we identified by biotin tagging > 350 RELA interactors from untreated and IL-1a-stimulated cells, including many TFs (47 % of all interactors) and > 50 epigenetic regulators belonging to different classes of chromatin remodeling complexes.
ORGANISM(S): Homo sapiens (Human) 
2024-11-04 | PXD045888 | Pride
Lc-msms Rela Affinity proteomics Turbo id Genetic networks P65 nf-kb Interactome 
UnknownA systematic umbrella review and meta-meta-analysis of eHealth and mHealth interventions for improving lifestyle behaviours.
Not available
S-EPMC11226451 | biostudies-literature
MetabolomicsGNPS Theonella swinhoei standards
purified standards of onnamide A, onnamide B and cyclotheonamide isolated from Theonella swinhoei (yellow chemotype, Hachijo Jima, Japan). Reference: Wilson MC, Mori T, R�ckert C, Uria AR, Helf MJ, Takada K, Gernert C, Steffens UA, Heycke N, Schmitt S, Rinke C, Helfrich EJ, Brachmann AO, Gurgui C, ...
ORGANISM(S): Theonella Swinhoei (yellow Chemotype Hachijo Jima, Japan) 
2014-05-23 | MSV000078669 | GNPS
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