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TranscriptomicsGene expression profiling by DNA microarray in Colo741 cell line transfected by KRas-G12D or KRas-G12V
Mutations of the proto-oncogene KRas, together with the inactivation of the onco-suppressor genes APC and TP53, are considered to have an important role both in the carcinogenesis and in the colorectal tumor progression. The oncogene K-ras has activating mutations, especially in codon 12, in about ...
ORGANISM(S): Homo sapiens 
2008-12-17 | E-GEOD-12398 | biostudies-arrayexpress
TranscriptomicsMurine lung tumors- HER2(V659E) and KRAS(G12V) vs normal lung
Transcriptiional profling of 13 normal lung samples, 18 lung KRAS(G12V) tumor samples, and 18 lung HER2(V659E) tumor samples 13 normal lung samples, 18 lung KRAS(G12V) tumor samples, and 18 lung HER2(V659E) tumor samples hybridized against Stratagene universal mouse reference RNA with dye swap
ORGANISM(S): Mus musculus 
2009-11-30 | E-GEOD-18784 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung epithelial cells ollowing oncogenic KRAS expression and TBK1 suppression or infection with oncogenic KRAS (G12V) - SuperSeries
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of clinically effective, molecularly targeted therapies in some cases, KRAS has rem...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-17672 | biostudies-arrayexpress
ProteomicsIdentification of KRas interactors in pancreatic cancer cell lines growing on matrix of different rigidities
KRas is one of the most prevalent mutations in pancreatic cancer and derives diverse signalling cascades to support tumour initiation and progression. Pancreatic ductal adenocarcinoma (PDAC) is the most diagnosed type of pancreatic cancer and is characterized to have a very dense stromal rigidity. T...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069885 | Pride
Lc-ms-ms Integrins Pancreatic cancer. pdac Mass spectrometry Kras 
TranscriptomicsTranscription profiling of human immortalized lung epithelial cells following infection with oncogenic KRAS (G12V)
The purpose of the dataset is to analyze expression of genes induced by KRAS; The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification of specific oncogenes has led to the development of cl...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-17671 | biostudies-arrayexpress
ProteomicsKRAS G12V digestion by 20S proteasome
KRAS is a well known tumor associated antigen. It’s a GTPase that functions as molecular switch in regulatory pathways responsible for proliferation and survival. It’s frequently mutated in a variety of cancers. One of the possible driver mutations is G12V substitution, which impairs KRAS GTPase act...
ORGANISM(S): Homo sapiens (Human) 
2019-10-24 | PXD015580 | Pride
Proteasome Cancer Kras Digestion Lc-ms/ms 
ProteomicsKRAS G12V spliced neoepitope is produced by proteasomes
This dataset contains further evidence that the HLA-A*02:01+ KRAS G12V+ spliced neoepitope we previously identified (Mishto et al., Front. Immunol. 2019) is produced by proteasomes in various experimental conditions
ORGANISM(S): Homo sapiens (Human) 
2022-09-05 | PXD024528 | Pride
Mass spectrometry Epitope discovery Peptide splicing Proteasome Cis-spliced peptides Kras 
ProteomicsIdentification of KRas interactors in PDAC cell lines
KRas is one of the most prevalent mutations in pancreatic cancer and derives diverse signalling cascades to support tumour initiation and progression. Pancreatic ductal adenocarcinoma (PDAC) is the most diagnosed type of pancreatic cancer and is characterized to have a very dense stromal rigidity. T...
ORGANISM(S): Homo sapiens (Human) 
2026-09-11 | PXD069779 | Pride
Lc-ms-ms Integrins Mass spectrometry Pancreatic cancer Cell signalling Kras 
GenomicsOncogenic KRAS(G12V) and BRAF(V600E) in intestinal organoids
Oncogenic KRAS(G12V) and BRAF(V600E) in intestinal organoids
PRJNA474218 | ENA
TranscriptomicsKRAS mutation (G12V) expression by pBABE-Puro vector in NCI-H1703 cells
The goal of this study was to determine genes affected by expressing KRAS mutation (G12V) in NCI-H1703 cells This data was used in Meng Wang et. al. Cancer Research 2016 to determine the alterations of gene expression profiling associated with expression of KRAS mutation (G12V). The experiment uses ...
ORGANISM(S): Homo sapiens 
2016-03-23 | E-GEOD-79486 | biostudies-arrayexpress
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