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ProteomicsEndothelial pathomechanisms in response to in vitro peritoneal dialysis fluid exposure
Loss of ultrafiltration capacity in peritoneal dialysis (PD) patients is often associated with peritoneal vascular changes, manifest as diabetes-like vasculopathy and angiogenesis. The endothelial monolayer lining the vessel lumen controls vessel barrier function and thereby influences peritoneal su...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022170 | Pride
Human umbilical vein endothelial cells Tmt Dialysis 
ProteomicsEndothelial pathomechanisms in response to in vito exposure to differentz peritoneal dialysis fluids
Loss of ultrafiltration capacity in peritoneal dialysis (PD) patients is often associated with peritoneal vascular changes, manifest as diabetes-like vasculopathy and angiogenesis. The endothelial monolayer lining the vessel lumen controls vessel barrier function and thereby influences peritoneal su...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034985 | Pride
Human umbilical vein endothelial cells Tmt Dialysis 
ProteomicsEndothelial pathomechanisms in response to in vivo peritoneal dialysis fluid exposure
Loss of ultrafiltration capacity in peritoneal dialysis (PD) patients is often associated with peritoneal vascular changes, manifest as diabetes-like vasculopathy and angiogenesis. The endothelial monolayer lining the vessel lumen controls vessel barrier function and thereby influences peritoneal su...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022183 | Pride
Tmt Dialysis Human arterioles 
Proteomics2D gel-based proteomics of primary human peritoneal mesothelial cells derived from omentum
Peritoneal mesothelial cells are harmed by peritoneal dialysis fluids (PDF) used in renal replacement therapy with peritoneal dialysis. The mechanisms of the cellular damage are not yet described in detail. Primary human peritoneal mesothelial cells derived from omentum of five donors were independe...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD011938 | Pride
Human Peritoneal dialysis Maldi 2d-dige 
ProteomicsMHC class I-mediated antigen presentation is independent of calreticulin
TMT-MS analysis of the proteome in whole cell lysates from primary murine neutrophil granulocytes and CD8+ T cells obtained from mice carrying a calreticulin knock out or oncogenic mutation (CALRdel52)
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD062085 | Pride
Calreticulin Knock out Cd8+ t cells Tandem mass tag mass spectrometry Mutated Mouse Tmt-ms Myeloproliferative neoplasm Neutrophil granulocytes Calrdel52 
ProteomicsCharacterization of fibrosis and senescence of human omental peritoneal mesothelial cells
Primary human omental mesothelial cells from multiple donors in a young (=normal) phase and senescent phase were treated with or without TGF-ß to induce fibrosis. Senescence was induced by up to 9 passages and confirmed by stopped cell division and positive senescence-associated β-galactosidase stai...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048090 | Pride
Fibrosis Peritoneal dialysis Senescence 
ProteomicsTMT-FASP-LC-MS analysis of peritoneal dialysis effluent
Peritoneal dialysis (PD) is a modality of renal replacement therapy in which the high volumes of available PD effluent (PDE) represents a rich source of biomarkers for monitoring disease and therapy. Although this information could help guiding the management of PD patients, little is known about th...
ORGANISM(S): Homo sapiens (Human) 
2012-12-13 | PXD006863 | Pride
Cytoprotection Tmt Peritoneal dialysis Plasma proteins Biomarkers 
ProteomicsTMT-FASP-LC-MS analysis of human pediatric omental biopsies
Cardiovascular disease (CVD) is exceedingly severe in patients with chronic kidney disease (CKD) and further aggravated by peritoneal dialysis (PD), exposing the patients to excessive amounts of intraperitoneal glucose. Children are devoid of pre-existing CVD and give insight into specific uremia an...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD006298 | Pride
Human Omentum Microdissection Peritoneal dialysis Arterioles Tmt Uremia Fasp 
ProteomicsTMTpro-SP3-LC-MS analysis of peritoneal dialysis effluent of a phase 2 randomized clinical trial
Peritoneal dialysis (PD) is a modality of renal replacement therapy in which the high volumes of available PD effluent (PDE) represents a rich source of biomarkers for monitoring disease and therapy. Although this information could help guiding the management of PD patients, little is known about th...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD050859 | Pride
Tmt Peritoneal dialysis 
ProteomicsProteome of hemodialysis filter membranes
Used hemodialysis filter membranes (HD filters) are discarded as waste products but represent a reservoir of valuable biological information. Numerous serum proteins are known to bind to HD filters, but whether this process selectively affects individual protein classes has not been adequately eluci...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035836 | Pride
Hemodialysis 
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