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OtherA combined omics approach to generate the surface atlas of human naive CD4+ T cells during early TCR activation.
Data from ProteomeXchange, PXD ID: PXD001432. File: SUK5557A8MA2__008-Spender2_3hP SUK5557A8MA2-40-215297.mzml. Published as part of . From the Abstract: {{i}} ... Periodate oxidation and aniline-catalyzed oxime ligation (PAL) technology was applied with subsequent quantitative LC-MS/MS (PAL-qLC-MS...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310020145 | GPMDB
Resource Reanalysis 
ProteomicsDynamic Palmitoylation Events Following T-Cell Receptor Signaling
Palmitoylation is the reversible addition of palmitate to cysteine via a thioester linkage. The reversible nature of this modification makes it a prime candidate as a mechanism for regulating signal transduction in T-cell receptor signaling. Following stimulation of the T-cell receptor we find a num...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018710 | Pride
Lat Dhhc20 Palmitoylation S-acylation Ti-vamp Palmitome Vamp7 Dhhc pats Tcr signaling In vitro palmitoylation T-cell activation Dhhc18 
ProteomicsTcell surface analysis - A combined omics approach to generate the surface atlas of human naive CD4+ T cells during early TCR activation
Naive CD4+ T cells are the common precursors of multiple effector and memory T cell subsets and possess a high plasticity in terms of differentiation potential. This stem-cell like character is important for cell therapies aiming at regeneration of specific immunity. Cell surface proteins are crucia...
ORGANISM(S): Homo sapiens (Human) 
2015-05-27 | PXD001432 | Pride
T-cells 
ProteomicsDynamic Palmitoylation Events Following T-Cell Receptor Signaling
Palmitoylation is the reversible addition of palmitate to cysteine via a thioester linkage. The reversible nature of this modification makes it a prime candidate as a mechanism for regulating signal transduction in T-cell receptor signaling. Following stimulation of the T-cell receptor we find a num...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018703 | Pride
Lat Dhhc20 Palmitoylation S-acylation Ti-vamp Palmitome Vamp7 Dhhc pats Tcr signaling In vitro palmitoylation T-cell activation Dhhc18 
TranscriptomicsExploring the role of sigma factor gene expression on production by Corynebacterium glutamicum: sigma factor H and FMN as example
Bacteria are known to cope with environmental changes by using alternative sigma factors binding to RNA polymerase core enzyme. Sigma factor is one of the targets to modify transcription regulation in bacteria and to influence production capacities. In this study, the effect of overexpressing all an...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2015-06-20 | E-GEOD-70017 | biostudies-arrayexpress
ProteomicsProteome analysis of AML cells upon CaSR-KO
Haematopoietic stem cells (HSC) reside in locations within the bone marrow microenvironment (BMM) featuring a slightly higher extracellular calcium ion concentration [eCa2+]. HSC respond to [eCa2+] via the G-protein coupled calcium-sensing receptor (CaSR), but the role of CaSR for leukaemia and leuk...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD035937 | Pride
Mouse Tmt Proteome Aml 
TranscriptomicsTranscription profiling of human Soas-2 cells infected with adenoviruses expressing p53 proteins with charge-neutralizing or charge-inverting mutations in the H1 helix to investigate the role of the dimerization interface in p53 function
To investigate the role of the dimerization interface for p53 function, we introduced modest charge-neutralizing (R181→L "EL") and more severe charge-inverting (R181→E "EE" and E180→R, R181→E "RE") mutations into the H1 helix of the full-length p53 molecule. To characterize t...
ORGANISM(S): Homo sapiens 
2010-04-01 | E-MEXP-1209 | biostudies-arrayexpress
ProteomicsIdentification of a novel class of cytotoxic granules as origin of supramolecular attack particles in T lymphocytes
Cytotoxic T lymphocytes (CTL) kill malignant and infected cells via cytotoxic proteins such as granzyme B (GzmB) that are released into the immunological synapse in the form of ~110 nm supramolecular attack particles (SMAPs). However, it is not known where SMAPs are stored in the cell and how they a...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD025055 | Pride
Exocytosis Proteomics Snare proteins Immunological synapse Cytotoxic granules Single core granules Supramolecular attack particles Total internal reflection fluorescence microscopy Correlative light and electron microscopy Multi core granules 
TranscriptomicsOncogenic Myc levels activate and repress specific genes to form characteristic expression profiles in human tumors
Myc was depleted in HeLa cells (ATCC CRL-1934) with an shRNA and the resulting expression profile changes mapped via microarrays. This study is the equivalent of E-MTAB-1524 . E-MTAB-1524 has been replaced by E-MTAB-1886.
ORGANISM(S): Homo sapiens 
2014-07-11 | E-MTAB-1886 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analysis of Sp2 Occupancy and Expression Profiling Establish Sp2 as a Sequence-specific Transcription Factor Regulating Fundamental Cellular Processes - Expression Profiling
Mouse embyronic fibroblasts (MEFs) were depleted for transcription factor Specificity Factor 2 (Sp2) via Cre-Recombinase, harvested either 7 days or several weeks post infection and their expression profile compared to mock-infected MEFs.
ORGANISM(S): Mus musculus 
2012-05-24 | E-MTAB-1015 | biostudies-arrayexpress
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