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ProteomicsCovalent targeting leads to the development of LIMK1 isoform-selective inhibitors
SM311 is a covalent LIMK1 inhibitor. To verify the specificity of SM311 towards LIMK1, a chemoproteomic competition experiment was set up with a biotin adduct of SM311, namely SM429. This adduct was immobilised on Streptactin beads and used to enrich proteins binding to SM429. Preincubation with an ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD063179 | Pride
Chemoproteomics Kinase Limk1 Human 
ProteomicsOnline parallel accumulation – serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer
In bottom-up proteomics, peptides are separated by liquid chromatography with elution peak widths in the range of seconds, while mass spectra are acquired in about 100 microseconds with time-of-fight (TOF) instruments. This allows adding ion mobility as a third dimension of separation. Among several...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-11-06 | PXD010012 | Pride
Tims Pasef Technological 
ProteomicsIdentification of interacting proteins of lncRNA HIF1α-AS1
LncRNA Hypoxia-inducible factor 1α-antisense 1 (HIF1α-AS1) is located on the antisense strand of the important Hypoxia-inducible factor 1α (HIF1α) gene, but being transcribed in antisense direction along the HIF1α promoter. Here we used the 3’end biotinylated HIF1a-AS1 RNA and a control RNA for RNA ...
ORGANISM(S): Homo sapiens (Human) 
2022-09-23 | PXD023512 | Pride
Interacting proteins Lncrna Lc-msms 
UnknownHyaline Cartilage Microtissues Engineered from Adult Dedifferentiated Chondrocytes: Safety and Role of WNT Signaling.
Not available
S-EPMC9801297 | biostudies-literature
UnknownSpread of Terbinafine-Resistant Trichophyton mentagrophytes Type VIII (India) in Germany-"The Tip of the Iceberg?"
Not available
S-EPMC7712673 | biostudies-literature
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