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This study involved evaluation of the tissue associated microbiome of the ileal pouch following surgery for ulcerative colitis (UC) or familial adenomatous polyposis (FAP). Individuals were recruited, with biopsies taken from the ileal pouch and the pre-pouch ileum, microbial DNA was extracted an...

During early postnatal development, hippocampal circuits are assembled through the coordinated navigation of axonal growth cones toward their synaptic targets. While growth cones are known to rely on local proteomic changes to interpret guidance cues, the developmental dynamics of their proteomic co...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-11 | PXD076616 | Pride
Leukemia cells instruct their surrounding bone marrow microenvironment (BMM) rendering it hospitable to leukemia cell survival. Conversely, how cells of the BMM influence leukemia progression is less well understood. Pleckstrin homology domain family M member 1 (PLEKHM1) serves as a hub between fusi...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-16 | PXD027044 | Pride
Leukemia cells instruct their surrounding bone marrow microenvironment (BMM) rendering it hospitable to leukemia cell survival. Conversely, how cells of the BMM influence leukemia progression is less well understood. Pleckstrin homology domain family M member 1 (PLEKHM1) serves as a hub between fusi...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-16 | PXD027041 | Pride
Haematopoietic stem cells (HSC) reside in locations within the bone marrow microenvironment (BMM) featuring a slightly higher extracellular calcium ion concentration [eCa2+]. HSC respond to [eCa2+] via the G-protein coupled calcium-sensing receptor (CaSR), but the role of CaSR for leukaemia and leuk...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD035937 | Pride
Cajal-Retzius (CR) cells are a transient neuron type that populate the postnatal hippocampus. The role of transient cell types and circuits have been vastly addressed in neocortical regions, but poorly studied in the hippocampus. To understand how CR cells persistence influences the maturation of hi...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042517 | Pride
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