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ProteomicsOxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B
The eukaryotic translation initiation factor 5B (eIF5B) is a homolog of the ancient IF2, a translation factor that facilitates initiator methionine-tRNAiMet (met-tRNAiMet) delivery to ribosomes in prokaryotes. IF2 evolved during early anaerobic cellular life and can be traced back to the last univer...
ORGANISM(S): Homo sapiens (Human) 
2018-01-03 | PXD006799 | Pride
Eif5b Oxygen Evolution Hypoxia Matrix Carbon metabolism If2 Translation 
ProteomicsSystemic remodeling of translation efficiencies on oxygen stimulus.
Protein concentrations evolve under greater evolutionary constraint than mRNA levels. In addition, translation efficiency of mRNA populations represents the chief determinant of basal protein concentrations. This raises a fundamental question as to how mRNA and protein levels are actively coordina...
ORGANISM(S): Homo sapiens (Human) 
2016-02-05 | PXD003037 | Pride
Cancer Silac Hypoxia Eif4e2 Translation Rna sequencing Eif4e 
ProteomicsProteomics and metabolomics reveal changes in cancer cells after alternation of SHMT2 expressions
In order to understand the underline mechanism of SHMT2 (serine hydroxymethyltransferase 2) effect on tumor growth, proteome and metabolome analysis were carried on a engineered HeLa cell line (HeLa-SHMT2-shSHMT2, short as HeLa-Ss), which has inducible SHMT2 over-expression or suppression by treatin...
ORGANISM(S): Homo sapiens (Human) 
2020-08-19 | PXD004954 | Pride
Metabolism Shmt2 Sodium benzoate Quantitative proteomics Interactome Lc-ms/ms 
ProteomicsComprehensive Identification of Phosphorylation Sites on the Numb Endocytic Adaptor Protein
Numb is an endocytic adaptor protein that functions in the endocytosis and intracellular trafficking of membrane receptors and adhesion molecules. Numb localization and function have been shown to be regulated by phosphorylation through atypcial protein kinase C at several key sites. Here, we use ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080218 | MassIVE
ProteomicsSystemic remodeling of translation efficiencies on oxygen stimulus.
Protein concentrations evolve under greater evolutionary constraint than mRNA levels. In addition, translation efficiency of mRNA populations represents the chief determinant of basal protein concentrations. This raises a fundamental question as to how mRNA and protein levels are actively coordina...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079962 | MassIVE
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
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