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MetabolomicsThe oncoprotein SET promotes serine-derived one-carbon metabolism by regulating SHMT2 enzymatic activity
Cancer cells frequently reprogram one-carbon metabolic pathways to fulfill their vigorous demands of biosynthesis and antioxidant defense for survival and proliferation. Dysfunction of oncogenes or tumor suppressor genes is critically involved in this process, but the precise mechanisms by which can...
2025-04-22 | MTBLS11711 | MetaboLights
MetabolomicsProteomic and metabolic changes in cancer cells after alternation of SHMT2 expressions
In order to understand the underline mechanism of SHMT2 (serine hydroxymethyltransferase 2) effect on tumor growth, proteome and metabolome analysis were carried on an engineered HeLa cell line (HeLa-SHMT2-shSHMT2, short as HeLa-Ss), which has inducible SHMT2 over-expression or suppression by treati...
2020-08-20 | MTBLS405 | MetaboLights
ProteomicsCancer proteome and metabolite changes linked to SHMT2
To screen for proximate and interacting proteins of SHMT2 in HeLa cells, the BioID method was employed, which consists of biotinylation of proteins in the vicinity of FlagBirAR118G –SHMT2 followed by streptavidin-based affinity capture and mass spectrometry identification. Experimental procedures we...
ORGANISM(S): Homo sapiens (Human) 
2020-08-12 | PXD004629 | Pride
Streptavidin Shmt2 Ms Bioid 
ProteomicsProteomics and metabolomics reveal changes in cancer cells after alternation of SHMT2 expressions
In order to understand the underline mechanism of SHMT2 (serine hydroxymethyltransferase 2) effect on tumor growth, proteome and metabolome analysis were carried on a engineered HeLa cell line (HeLa-SHMT2-shSHMT2, short as HeLa-Ss), which has inducible SHMT2 over-expression or suppression by treatin...
ORGANISM(S): Homo sapiens (Human) 
2020-08-19 | PXD004954 | Pride
Metabolism Shmt2 Sodium benzoate Quantitative proteomics Interactome Lc-ms/ms 
GenomicsSHMT2 drives the progression of colorectal cancer by regulating UHRF1 expression
SHMT2 drives the progression of colorectal cancer by regulating UHRF1 expression
PRJNA786490 | ENA
GenomicsTranscriptome sequencing of pancreatic cancer cells transfected with SHMT2 knockdown lentivirus (human).
Transcriptome sequencing of pancreatic cancer cells transfected with SHMT2 knockdown lentivirus (human).
PRJNA1367190 | ENA
GenomicsEffect of knockdown SHMT2 on gene expression in LX2 cells.
Effect of knockdown SHMT2 on gene expression in LX2 cells.
PRJNA867309 | ENA
GenomicsSHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice
SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice
PRJNA1046381 | ENA
TranscriptomicsSHMT2 drives the progression of colorectal cancer by regulating UHRF1 expression
Introduction: Serine hydroxymethyltransferase 2 (SHMT2) has a critical role in serine-glycine metabolism to drive cancer cell proliferation. Yet, the function of SHMT2 in tumorigenesis, especially in human colorectal cancer (CRC) progression, remains largely unclear. Materials and Methods: CRC and p...
ORGANISM(S): Homo sapiens 
2022-03-02 | GSE190234 | GEO
GenomicsThe serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing
PRJNA580033 | ENA
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