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TranscriptomicsExpression profiling of KSR1-/- MEFs expressing KSR1 and/or H-RasV12
We engineered KSR1-/- mouse embryonic fibroblasts (MEFs) to express GFP alone, KSR1 or RasV12 and GFP, or KSR1, H-RasV12 and GFP, and performed gene expression profiling on all 4 cell lines. Each cell line was measured in triplicate: 1. GFP alone 2. H-RasV12 and GFP 3. KSR1 and GFP 4. KSR1, H-RasV12...
ORGANISM(S): Mus musculus 
2011-04-02 | E-GEOD-28228 | biostudies-arrayexpress
Proteomics(Full Proteome) Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells
KSR1 is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in mutant RAS mediated transformation. Here, we examined the role of KSR1 in mutant BRAF transformation. We ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD036265 | Pride
Ksr1 Proteomics. Ras-raf-mek-erk pathway Cancer 
Proteomics(AP-MS) Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells
KSR1 is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in mutant RAS mediated transformation. Here, we examined the role of KSR1 in mutant BRAF transformation. We ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036261 | Pride
Ksr1 Ras_raf-mek-erk pathway Melanoma Apoptosis Proliferation Senescence 
TranscriptomicsExpression profiling of KSR1-/- MEFs expressing KSR1 and/or H-RasV12
We engineered KSR1-/- mouse embryonic fibroblasts (MEFs) to express GFP alone, KSR1 or RasV12 and GFP, or KSR1, H-RasV12 and GFP, and performed gene expression profiling on all 4 cell lines.
ORGANISM(S): Mus musculus 
2011-04-02 | GSE28228 | GEO
ProteomicsKSR1 and genotoxic agents in MCF7 (SILAC-MS)
We use KSR1 overexpression and exposure to doxorubin or etoposide in MCF7 cells to reveal a comprehensive repertoire of thousands of proteins identified in each dataset and compare the unique proteomic profile as well as functional connections modulated by KSR1 after doxorubicin (Doxo-KSR1) or etop...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD002233 | Pride
Doxorubicin Ksr1 Breast cancer Silac Etoposide 
GenomicsNext generation sequencing analysis of control and KSR1 knockdown CRC cell line translatomes.
Next generation sequencing analysis of control and KSR1 knockdown CRC cell line translatomes.
PRJNA690941 | ENA
GenomicsMus musculus
Expression profiling of KSR1-/- MEFs expressing KSR1 and/or H-RasV12
PRJNA139617 | ENA
UnknownSignaling dynamics of the KSR1 scaffold complex.
Not available
S-EPMC2708738 | biostudies-literature
Genomics
Candida albicans KSR1
PRJNA1063495 | ENA
TranscriptomicsNext generation sequencing analysis of control and KSR1 knockdown CRC cell line translatomes.
KSR1 signaling alters the translational landscape of human CRC cells to support their survival. To determine the effect of KSR1 on translatomes in colon cancer cells, we performed genome-wide polysome profiling. We stably expressed short hairpin RNA (shRNA) constructs targeting KSR1 or a non-targeti...
ORGANISM(S): Homo sapiens 
2021-01-10 | GSE164492 | GEO
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