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TranscriptomicsThe ß-importin KAP8 (Pse1/Kap121) is required for nuclear import of the cellulase transcriptional regulator XYR1, asexual sporulation and stress resistance in Trichoderma reesei
The ascomycete Trichoderma reesei is an industrial producer of cellulolytic and hemicellulolytic enzymes and also serves as a model for investigations on these enzymes and their genes. Most of them are obligatorily dependent on the Zn(II)Cys(VI) transcriptional activator XYR1. XYR1 is constitutively...
ORGANISM(S): Trichoderma reesei 
2015-03-03 | E-GEOD-59600 | biostudies-arrayexpress
ProteomicsComparative exo-proteomic analysis of Trichoderma antagonists induced by oomycete mycelium highlights diverse antagonism strategies
Plant-beneficial fungi from the genus Trichoderma (Hypocreales, Ascomycota) can control oomyceteous plant-pathogenic Pythium myriotylum (Peronosporales, Oomycota) and thus serve as bioeffectors for the eco-friendly products of crop protection. However, the underlying mechanisms of microbe-microbe in...
ORGANISM(S): Trichoderma asperellum CBS 433.97 Trichoderma virens Gv29-8 Hypocrea jecorina (strain QM6a) (Trichoderma reesei) Trichoderma atroviride IMI 206040 Trichoderma parepimyces Trichoderma guizhouense 
2024-07-19 | PXD051895 | Pride
Trichoderma Exo-proteins Hydrolyase Antagonism 
ProteomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
Insulin expression is restricted to the pancreatic beta cells, which are physically or functionally depleted in diabetes. Identifying targetable pathways repressing insulin in non-beta cells, particularly in the developmentally related glucagon-secreting alpha cells, is an important aim of regenerat...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-01 | PXD030363 | Pride
Pancreatic islets Chromatin remodelers Alpha cells Beta cells Smndc1 Rnai screen Splicing Insulin transcription 
ProteomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
Insulin expression is restricted to the pancreatic beta cells, which are physically or functionally depleted in diabetes. Identifying targetable pathways repressing insulin in non-beta cells, particularly in the developmentally related glucagon-secreting alpha cells, is an important aim of regenerat...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-01 | PXD030361 | Pride
Pancreatic islets Chromatin remodelers Alpha cells Beta cells Smndc1 Rnai screen Splicing Insulin transcription 
ProteomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
Insulin expression is restricted to the pancreatic beta cells, which are physically or functionally depleted in diabetes. Identifying targetable pathways repressing insulin in non-beta cells, particularly in the developmentally related glucagon-secreting alpha cells, is an important aim of regenerat...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-01 | PXD030362 | Pride
Pancreatic islets Chromatin remodelers Alpha cells Beta cells Smndc1 Rnai screen Splicing Insulin transcription 
TranscriptomicsComparative analysis of the Trichoderma reesei transcriptome during growth on the cellulase inducing substrates wheat straw and lactose
We have examined and compared the transcriptome of T. reesei growing on wheat straw and lactose as carbon sources under otherwise similar conditions. Gene expression on wheat straw exceeded that on lactose, and 1619 genes were found to be only induced on wheat straw but not on lactose. They compris...
ORGANISM(S): Trichoderma reesei QM9414 
2013-09-17 | E-GEOD-46155 | biostudies-arrayexpress
UnknownPooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time.
Not available
S-EPMC7706735 | biostudies-literature
ProteomicsPharmacological perturbation of the phase-separating protein SMNDC1
SMNDC1 is an essential splicing factor that, like its better-studied paralog SMN, binds to di-methylated arginines using its Tudor domain. The specific contributions of the SMNDC1 Tudor domain to protein-protein interactions, subcellular localization, and molecular function have not been studied in ...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-04 | PXD037092 | Pride
Pancreatic alpha cells Tudor domain Small molecule inhibitor Nmr structure Nuclear speckles Splicing Chemical screening 
UnknownSu(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila.
Not available
S-EPMC534657 | biostudies-literature
ProteomicsCalreticulin mutated hematopoietic cells are vulnerable to ATR-CHK1 pathway inhibition
Disease frameshift mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF). To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we aimed to search for small molecule drugs th...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD026803 | Pride
Mouse Mpn Calreticulin mutant Myeloproliferative neoplasms Atr-chk1 pathway 
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