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ProteomicsDefective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation
Proteomics and phosphoproteomics analyses of two human pluripotent stem cell (hPSC) lines with stable insulin receptor knock down. 6-plex TMT-based strategy was applied to compare control versus insulin receptor (IR) knockdown (n=3 replicates for each condition) for each cell lines (CHB8 and H9). D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-16 | MSV000085298 | MassIVE
ProteomicsCharacterization of cytokine treatment on human pancreatic islets by top-down proteomics
Top-down proteomic data from 6 human islet donors; islets were treated with interferon gamma (IFN-gamma) and interleukin-1 beta (IL-1 beta). Time points include t=0 (control) and t=24 hours for each donor. Samples were reduced and alkylated, then analyzed by LC-MS/MS. Data was searched with TopPIC u...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-05-06 | MSV000097810 | MassIVE
ProteomicsHepatic SerpinA1 Improves Energy and Glucose Metabolism through Regulation of Preadipocyte Proliferation and UCP1 Expression
Fat tissue inducible specific IGF1R and IR (insulin receptor) KO mouse model to investigate the effect of insulin resistance on mature adipocytes. Mouse serum proteomics performed using TMT-10 analyses. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-21 | MSV000093454 | MassIVE
ProteomicsA Signal Amplification via Boosting with Isobaric Labeling Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells
Despite recent advances in MS-based proteomics, comprehensive phosphoproteomics analysis of small populations of cells remains a daunting task, due primarily to the general lack of sufficient MS signals from such limited amounts of samples. In light of the unique multiplexing feature of isobaric lab...
ORGANISM(S): Homo Sapiens (human) 
2019-03-15 | PXD011857 | JPOST Repository
ProteomicsPancreatic beta cell proteome with increased proliferation in NOD mice
We investigated the pancreatic beta cell proteome changes in NOD-LIRKO vesus NOD where beta cell mass was enhanced early in life. Proteomics data is derived from FACS-sorted beta cells at 8 weeks and 12 weeks.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-03-14 | MSV000083576 | MassIVE
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