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ProteomicsGefitinib results in robust host-directed immunity against Salmonella infection through proteo-metabolomic reprogramming.
The rise of antibiotic-resistant strains of Salmonella has demand the development of alternative therapeutic strategies. Recent studies have shown that targeting host factors may provide an alternative approach for the treatment of intracellular pathogens. Host-directed therapy (HDT) modulates host ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-26 | PXD024771 | Pride
Salmonella Proteo-metabolomic Dia Swath-ms Thp-1 
ProteomicsExploiting Dynamics of Genomic Islands to Edit the Genome of Vibrio cholerae and Identify Novel Interactions Between Core and Acquired Genome
Horizontally acquired genetic elements (HGEs) plays a major for determination of virulence, antimicrobial resistance, adaptation and evolution in pathogenic bacteria. Conserved integrative mobile genetic elements (MGEs) of Vibrio cholerae contribute in the disease development, antimicrobial resista...
ORGANISM(S): Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 
2020-09-28 | PXD017801 | Pride
Dia Vibrio cholerae Swath-ms 
Proteomics“Trading virulence forsurvival”:Metabolic pathway switch is a key mechanism for survival of Macrophomina phaseolina upon Burkholderia contaminans challenge
Macrophominaphaseolina is attributed to infect a wide range of plants. There are not a successful strategies to eradicate the fungus from the soil. In this study, a jute endophytic bacteria, Burkholderiacontaminans has been found to have a promising effect in controlling M. phaseolinain in vitro cul...
ORGANISM(S): Macrophomina phaseolina 
2020-02-18 | PXD009121 | Pride
Macrophominaphaseolina Burkholderiacontaminans Oxidative stress Itraq 
ProteomicsIdentification and characterization of O-GlcNAc modifications of a conserved orthopoxvirus core protein
O-GlcNAcylation is a dynamic and reversible post-translational modification involving the attachment of a single β-N-acetylglucosamine (GlcNAc) moiety to the hydroxyl groups of serine or threonine residues. This modification occurs in thousands of cytoplasmic, nuclear, and mitochondrial proteins in ...
ORGANISM(S): Vaccinia virus WR 
2025-05-21 | PXD062753 | Pride
A4 O-glcnacylation Orthopoxvirus O-glcnac 
ProteomicsVaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy
This study investigates the dynamic alterations in high vaginal fluid (HVF) proteome and its correlation with physiological changes during progression of term pregnancy. The HVF samples were collected at three time points as defined as V1 (6-12 weeks), V2 (18-20 weeks) and V3 (26-28 weeks) and SWAT...
ORGANISM(S): Homo sapiens (Human) 
2021-01-28 | PXD021811 | Pride
Pregnancy Human vaginal fluid Longitudinal study Mrm Swath ms 
ProteomicsVaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy
This study investigates the dynamic alterations in high vaginal fluid (HVF) proteome and its correlation with physiological changes during progression of term pregnancy. The HVF samples were collected at three time points as defined as V1 (6-12 weeks), V2 (18-20 weeks) and V3 (26-28 weeks) and SWAT...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD014846 | Pride
Pregnancy Human vaginal fluid Longitudinal study Swath ms 
ProteomicsSalivary proteome signatures in the early and middle stages of human pregnancy with term birth outcome
This prospective study is to find changes in salivary protein expressions from first to early third trimester of pregnancy in normal term birth using SWATH-MS strategy. Saliva at three periods of gestation, 6-13 (V1), 18-21(V2), and 26-29 (V3) weeks from 20 singleton pregnant women were used in ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD014800 | Pride
Pregnancy Swath Human Saliva 
UnknownThe Virtual Summer Research Program: supporting future physician-scientists from underrepresented backgrounds.
Not available
S-EPMC9549583 | biostudies-literature
UnknownMechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.
Not available
S-EPMC10005179 | biostudies-literature
UnknownPartial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling.
Not available
S-EPMC6925349 | biostudies-literature
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