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ProteomicsThe RNA helicase Dbp10 coordinates assembly factor association with PTC formation during ribosome biogenesis
During ribosome biogenesis a plethora of assembly factors and essential enzymes drive the unidirectional maturation of nascent pre-ribosomal subunits. The DEAD-box RNA helicase Dbp10 is suggested to restructure pre-ribosomal rRNA of the evolving peptidyl-transferase center (PTC) on nucleolar ribosom...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-05-22 | PXD046068 | Pride
Ribosome assembly. pre-60s Assembly factors S. cerevisiae 
ProteomicsHistone H3 tail interactome in MPC11 murine myeloma cells
We have used peptide capture in conjunction with super-SILAC quantification to carry out an unbiased high-throughput analysis of the composition of protein complexes that bind to histone H3K9/S10 and H3K27/S28 methyl-phospho modifications. We compared binding profiles of nuclear proteins from MPC11 ...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-04 | PXD001273 | Pride
Lc-msms Histone modification Peptide capture Histone h3 tail interactome 
ProteomicsPerilipin 5-mediated lipid droplet-mitochondria coupling determines mitochondrial capacity
Disturbances in lipid homeostasis can cause mitochondrial dysfunction and lipotoxicity requiring tight regulation of intracellular lipid metabolism and fatty acid (FA) flux. Perilipin 5 (PLIN5) decorates intracellular lipid droplets (LD) in oxidative tissues and controls triacylglycerol (TG) turnove...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD028541 | Pride
Mitochondria Lipid droplet Fatty acid metabolism Plin5 
Transcriptomicssingle-cell RNA-seq of of dermal fibroblasts
Dermal fibroblasts from human, rhesus macaque, mouse and rat, stimulated with dsRNA (poly I:C) in a time course of 0,2,4 and 8 hours, profiled using the Smart-seq2 protocol.
The innate immune response - the expression programme that is initiated once a pathogen is sensed - is known to be variable...
ORGANISM(S): Macaca mulatta 
2018-07-06 | E-MTAB-5920 | biostudies-arrayexpress
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