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TranscriptomicsKupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity.
Kupffer cells have been implicated in the pathogenesis of various liver diseases. However, their involvement in metabolic disorders of the liver, including fatty liver disease, remains unclear. The present study sought to determine the impact of Kupffer cells on hepatic triglyceride storage and to e...
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-33044 | biostudies-arrayexpress
ProteomicsHIF-2a drives hepatic Kupffer cell death and liver inflammation in nonalcoholic steatohepatitis
Proinflammatory activation of hepatic macrophages plays a key role in the development of nonalcoholic steatohepatitis (NASH). This involves increased embryonic hepatic Kupffer cell (KC) death, facilitating the placement of KCs with bone marrow-derived recruited hepatic macrophages (RHMs) that highly...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD040457 | Pride
Nonalcoholic fatty liver disease (nafld) Macrophage Obesity Proinflammatory macrophage activation Nonalcoholic steatohepatitis (nash) Inflammation/metaflammation Hif-2a Kupffer cell death Hypoxia 
UnknownThe role of heme in sepsis induced Kupffer cell PANoptosis and senescence.
Not available
S-EPMC11993645 | biostudies-literature
UnknownKupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice.
Not available
S-EPMC8564511 | biostudies-literature
UnknownUptake of Plasmodium chabaudi hemozoin drives Kupffer cell death and fuels superinfections.
Not available
S-EPMC9671901 | biostudies-literature
UnknownKupffer cell-derived TNF-α promotes hepatocytes to produce CXCL1 and mobilize neutrophils in response to necrotic cells.
Not available
S-EPMC5833701 | biostudies-literature
UnknownDHA/AA alleviates LPS-induced Kupffer cells pyroptosis via GPR120 interaction with NLRP3 to inhibit inflammasome complexes assembly.
Not available
S-EPMC7803970 | biostudies-literature
UnknownMechanistic Differences in Cell Death Responses to Metal-Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes.
Not available
S-EPMC7263057 | biostudies-literature
GenomicsKupffer Cell Calibration of T Cell Responses via VSIG4-CD5 Interaction Promotes Tumor Evasion [bulkRNA]
Kupffer Cell Calibration of T Cell Responses via VSIG4-CD5 Interaction Promotes Tumor Evasion [bulkRNA]
PRJNA1414400 | ENA
UnknownHIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis.
Not available
S-EPMC11665927 | biostudies-literature
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