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ProteomicsAssessing actin-pathway interactions in variants identified in patients with ocular coloboma
We used whole exome sequence to identify de novo mutations in patients with ocular coloboma. Three of these encoded actin pathway components, ACTG1, TWF1 and LCP1. Mass spectrometry-based interactomes of wild-type and mutant proteins were performed to reveal altered functional interactions for all...
ORGANISM(S): Homo sapiens (Human) 
2017-05-24 | PXD005090 | Pride
Gfp-trap  actin  actg1  twf1  lcp1  hek293 
ProteomicsCharacterisation of the Tilapia Lake Virus proteome
We investigated expression and localisation of all predicted proteins of Tilapia Lake Virus (TiLV) using in vitro translation, cell expression systems, and mass spectrometry, confirming major polypeptides from each segment and discovering an additional 11th protein, S9-F3, from an alternative readin...
ORGANISM(S): Tilapia (ncbitaxon:8126) 
MSV000099204 | MassIVE
ProteomicsTWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression
Cholangiocarcinoma is a cancer of the hepatic bile ducts that is typically detected at a stage too advanced for resection. Additionally, chemotherapy is of limited efficacy, hence, novel therapeutic approaches are urgently required, including targeting of the cancer stroma. A macrophage-derived sign...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084273 | MassIVE
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