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ProteomicsLC-MS/MS analysis: coIP of Tssc4-Flag from nuclear extracts of HEK293 cells
Interactome analysis of human Flag-tagged Tssc4, Tssc4 mutant and background control. The coIP's (n=3) were performed from nucelar extract of HEK293 cells followed by LC-ESI-MS/MS analysis.
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD029493 | Pride
Lc-ms/ms coip 
ProteomicsWhen less is more – A fast TurboID KI approach for high sensitivity endogenous interactome mapping
In recent years, proximity labelling has established itself as an unbiased and powerful approach to map the interactome of specific proteins. While physiological expression of the labelling enzyme is beneficial for the mapping of interactors, generation of the desired cell lines remains time-consumi...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD051393 | Pride
Interactome mapping Turboid Ap Lc-ms/ms 
ProteomicsIntact MS of tubulin from murine embryonic stem cells
Mitotic spindles assemble in a crowded cytoplasm whose physical properties can change during functional transitions between cell states. How cytoplasmic properties influence spindle architecture and scaling remains unknown. Spindle scaling relationships have been described in early animal developmen...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-28 | PXD061228 | Pride
Mouse Intact ms Tubulin 
ProteomicsHeteroresistance in Enterobacter cloacae complex caused by cell-to-cell variation in transient gene duplication-amplification events
Heteroresistance in bacteria describes a subpopulational phenomenon of transient antibiotic resistance variation among cells of a generally susceptible population. Here, we investigated the molecular mechanisms and phenotypic characteristics underlying heteroresistance to ceftazidime (CAZ) in a clin...
ORGANISM(S): Enterobacter cloacae 
2024-10-17 | PXD056728 | Pride
Lc-ms/ms 
ProteomicsPopulation context drives cell-to-cell variability in interferon response in epithelial cells
Isogenic cells respond in a heterogeneous manner to interferon. Using a micropatterning approach combined with high-content imaging and spatial analyses, we characterized how the population context (position of a cell with respect to neighboring cells) of epithelial cells affects single cell respons...
ORGANISM(S): Homo sapiens (Human) 
2024-02-07 | PXD047936 | Pride
Lc-msms 
ProteomicsSalmonella Typhimurium proteome analysis albicidin resistance
Salmonella Typhimurium proteome changes induced by resistance development against the antibiotic albicidin.
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 
2023-07-14 | PXD031944 | Pride
Lc-msms Albicidin Salmonella typhimurium 
ProteomicsLC-MS/MS analysis: coIP of C9ORF78-Flag from nuclear extracts of HEK293 cells
Interactome analysis of human Flag-tagged C9ORF78, C9ORF78 mutant (R41A) and background control. The coIP's (n=3) were performed from nucelar extract of HEK293 cells followed by LC-ESI-MS/MS analysis.
ORGANISM(S): Homo sapiens (Human) 
2022-02-07 | PXD031482 | Pride
Hek293 cells 
ProteomicsImpact of suppression of the SOS response on protein expression in clinical isolates of Escherichia coli under antimicrobial pressure of ciprofloxacin
Suppression of the SOS response in combination with drugs has been proposed as a potential target to tackle antimicrobial resistance. The SOS response is the pathway used to repair bacterial DNA damage induced by antimicrobials such as quinolones. The extent of lexA-regulated protein expression and...
ORGANISM(S): Escherichia coli 
2024-04-04 | PXD050358 | Pride
Escherichia coli. ciprofloxacin 
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