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ProteomicsIdentification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells
Potassium channels regulate membrane potential, calcium flux, cellular activation and effector functions of adaptive and innate immune cells. The voltage-activated Kv1.3 channel is an important regulator of T cell-mediated autoimmunity and microglia-mediated neuroinflammation. Kv1.3 channels, via pr...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD059644 | Pride
Autoimmune disease T-cells Potassium channel Kv1.3 
ProteomicsProximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia.
Microglia are resident immune cells of the brain and regulate its inflammatory state. In neurodegenerative diseases, microglia transition from a homeostatic state to a state referred to as disease associated microglia (DAM). DAM express higher levels of proinflammatory signaling molecules, like STAT...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-05-06 | PXD049433 | Pride
Proximity labeling Neurodegeneration Neuroinflammation Kv1.3 potassium channel Microglia 
ProteomicsIdentification of novel Kv1.3 channel dependent mechanisms in microglial activation
Pro-inflammatory microglia contribute to disease progression in neuroinflammatory and neurodegenerative diseases. We identify novel Kv1.3 channel-dependent molecular and cellular mechanisms during microglial activation and unravel a Kv1.3-dependent pathway for MHCI-restricted antigen presentation by...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD006753 | Pride
Inflammation Potassium channel Systems pharmacology Microglia Bv2 
TranscriptomicsKv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology
Abstract Inhibition of voltage-gated potassium channel Kv1.3 is a therapeutic strategy to curb microglia-mediated neuroinflammation in neurodegeneration, although the cellular and signaling mechanisms of disease-modification by Kv1.3 blockers are unclear. In this study, we delineate protective mecha...
ORGANISM(S): Mus musculus 
2026-07-15 | GSE338689 | GEO
ProteomicsKv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology
Kv1.3, a voltage-gated potassium channel, is a therapeutic target in various neuropathological conditions. In rodent models, Kv1.3 inhibitors have been shown to inhibit disease-induced neuroinflammation. However, the cellular mechanisms of disease-modification by Kv1.3 blockers and the signaling pat...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-13 | PXD072055 | Pride
Interferon Resilience alzheimer’s disease Transcriptomics  snrna seq Kv1.3 Proteomics Microglia 
ProteomicsKv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology
Kv1.3, a voltage-gated potassium channel, is a therapeutic target in various neuropathological conditions. In rodent models, Kv1.3 inhibitors have been shown to inhibit disease-induced neuroinflammation. However, the cellular mechanisms of disease-modification by Kv1.3 blockers and the signaling pat...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-13 | PXD071599 | Pride
Interferon Resilience alzheimer’s disease Transcriptomics  snrna seq Kv1.3 Proteomics Microglia 
Genomics
KV1.3 INTACT CELL INTERACTOME
PRJNA902542 | ENA
GenomicsKv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology
Kv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology
PRJNA1495533 | ENA
UnknownBioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.
Not available
S-EPMC11373599 | biostudies-literature
UnknownThe C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane.
Not available
S-EPMC5897520 | biostudies-literature
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