Identification of novel Kv1.3 channel dependent mechanisms in microglial activation

ABSTRACT: Pro-inflammatory microglia contribute to disease progression in neuroinflammatory and neurodegenerative diseases. We identify novel Kv1.3 channel-dependent molecular and cellular mechanisms during microglial activation and unravel a Kv1.3-dependent pathway for MHCI-restricted antigen presentation by microglia to CD8+ T cells.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Microglial Cell

DISEASE(S): Alzheimer's Disease

SUBMITTER: Eric Dammer  

LAB HEAD: Nicholas T. Seyfried

PROVIDER: PXD006753 | Pride | 2018-10-24

REPOSITORIES: Pride