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ProteomicsIdentification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells
Potassium channels regulate membrane potential, calcium flux, cellular activation and effector functions of adaptive and innate immune cells. The voltage-activated Kv1.3 channel is an important regulator of T cell-mediated autoimmunity and microglia-mediated neuroinflammation. Kv1.3 channels, via pr...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD059644 | Pride
Autoimmune disease T-cells Potassium channel Kv1.3 
ProteomicsProximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia.
Microglia are resident immune cells of the brain and regulate its inflammatory state. In neurodegenerative diseases, microglia transition from a homeostatic state to a state referred to as disease associated microglia (DAM). DAM express higher levels of proinflammatory signaling molecules, like STAT...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-05-06 | PXD049433 | Pride
Proximity labeling Neurodegeneration Neuroinflammation Kv1.3 potassium channel Microglia 
ProteomicsIdentification of novel Kv1.3 channel dependent mechanisms in microglial activation
Pro-inflammatory microglia contribute to disease progression in neuroinflammatory and neurodegenerative diseases. We identify novel Kv1.3 channel-dependent molecular and cellular mechanisms during microglial activation and unravel a Kv1.3-dependent pathway for MHCI-restricted antigen presentation by...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD006753 | Pride
Inflammation Potassium channel Systems pharmacology Microglia Bv2 
UnknownThe voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation.
Not available
S-EPMC8953450 | biostudies-literature
UnknownProximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia.
Not available
S-EPMC11780389 | biostudies-literature
UnknownMitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes.
Not available
S-EPMC2567458 | biostudies-literature
UnknownStructures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.
Not available
S-EPMC9253088 | biostudies-literature
UnknownMechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit.
Not available
S-EPMC5368567 | biostudies-literature
UnknownPotassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease.
Not available
S-EPMC4402159 | biostudies-literature
UnknownHg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family.
Not available
S-EPMC3340210 | biostudies-literature
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