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ProteomicsKv11.1 (hERG) Protein Interaction Networks Connect Endocytic Trafficking to Polygenic Influences on Cardiac Repolarization
Polygenic scores (PGS) capture the combined effect of many common genetic variants on quantitative traits and disease risk, yet their functional consequences at the protein level remain poorly defined. Here, we integrated quantitative and interaction proteomics to resolve how polygenic liability for...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD077616 | Pride
Polygenic scores Herg Cardiomyocytes Arrhythmia Kv11.1 Human induced pluripotent stem cells 
UnknownMechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: interaction of trafficking and gating.
Not available
S-EPMC3530382 | biostudies-literature
UnknownThe S1 helix critically regulates the finely tuned gating of Kv11.1 channels.
Not available
S-EPMC5418064 | biostudies-literature
UnknownActivation of Kv11.1 potassium channel suppresses non-small cell lung cancer growth by promoting c-Myc degradation.
Not available
S-EPMC12635092 | biostudies-literature
UnknownKv11.1-dependent senescence activates a lethal immune response via tumor necrosis factor alpha.
Not available
S-EPMC11981764 | biostudies-literature
UnknownC-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.
Not available
S-EPMC3808384 | biostudies-literature
UnknownPreclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer.
Not available
S-EPMC5790466 | biostudies-literature
UnknownTyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation.
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S-EPMC5016128 | biostudies-literature
UnknownRegulation of Kv11.1 potassium channel C-terminal isoform expression by the RNA-binding proteins HuR and HuD.
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S-EPMC6314146 | biostudies-literature
UnknownAssociation of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems.
Not available
S-EPMC1635398 | biostudies-literature
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