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UnknownAdiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.

Objective

To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.

Design

Individual participant data meta-analysis.

Setting

Cohorts f...
S-EPMC6481269 | biostudies-literature
UnknownEffect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.

Importance

Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF).

Objective

To determine the effect of the phosphodiesterase-5...
S-EPMC3835156 | biostudies-literature
ProteomicsCYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death
ECL1_1173151: FLAG-IP, HEK293T transfected with pcDNA3.1 vector expressing N-term-3XFLAG tagged GFP ECL1_1173152: FLAG-IP, HEK293T transfected with pcDNA3.1 vector expressing N-term-3XFLAG tagged GFP ECL1_1173153: FLAG-IP, HEK293T transfected with pcDNA3.1 vector expressing N-term-3XFLAG tagged CYP1...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Coxiella Burnetii (ncbitaxon:777) 
2024-12-23 | MSV000096725 | MassIVE
UnknownDiagnosis of thyroid nodules on ultrasonography by a deep convolutional neural network.
The purpose of this study was to evaluate and compare the diagnostic performances of the deep convolutional neural network (CNN) and expert radiologists for differentiating thyroid nodules on ultrasonography (US), and to validate the results in multicenter data sets. This multicenter retrospective s...
S-EPMC7498581 | biostudies-literature
UnknownEffect and Safety of Meropenem-Vaborbactam versus Best-Available Therapy in Patients with Carbapenem-Resistant Enterobacteriaceae Infections: The TANGO II Randomized Clinical Trial.

Introduction

Treatment options for carbapenem-resistant Enterobacteriaceae (CRE) infections are limited and CRE infections remain associated with high clinical failure and mortality rates, particularly in vulnerable patient populations. A Phase 3, multinational, open-label, randomized contro...
S-EPMC6249182 | biostudies-literature
UnknownThe effect of LRRK2 loss-of-function variants in humans.
Human genetic variants predicted to cause loss-of-function of protein-coding genes (pLoF variants) provide natural in vivo models of human gene inactivation and can be valuable indicators of gene function and the potential toxicity of therapeutic inhibitors targeting these genes1,2. Gain-...
S-EPMC7303015 | biostudies-literature
UnknownThe Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia.
Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical responses. Therefore, the Society for Immunotherapy o...
S-EPMC5168808 | biostudies-literature
UnknownUltrafiltration in decompensated heart failure with cardiorenal syndrome.

Background

Ultrafiltration is an alternative strategy to diuretic therapy for the treatment of patients with acute decompensated heart failure. Little is known about the efficacy and safety of ultrafiltration in patients with acute decompensated heart failure complicated by persistent conges...
S-EPMC3690472 | biostudies-literature
UnknownDiuretic strategies in patients with acute decompensated heart failure.

Background

Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use.

Methods

In a prospective, double-blind, randomized trial, we assigned 308 patients with acute decompensated heart...
S-EPMC3412356 | biostudies-literature
UnknownNiraparib and Abiraterone Acetate for Metastatic Castration-Resistant Prostate Cancer.

Purpose

Metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease with current standard-of-care therapies. Homologous recombination repair (HRR) gene alterations, including BRCA1/2 alterations, can sensitize cancer cells to poly (ADP-ribose) polymerase inhibitio...
S-EPMC10431499 | biostudies-literature
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