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MetabolomicsEnterotoxigenic Bacteroides fragilis Exacerbates Alcoholic Liver Disease by Driving Host Metabolic Reprogramming via the Tryptophan-Kynurenine-Retinol Pathway

Background & Aims: Alcoholic liver disease (ALD) is a major public health concern. Gut dysbiosis plays a critical role in its pathogenesis, yet the specific microbial and functional shifts driving ALD progression require further elucidation. This study aims to characterize these alterations a...

2026-02-06 | MTBLS13858 | MetaboLights
MetabolomicsEnterotoxigenic Bacteroides fragilis Exacerbates Alcoholic Liver Disease by Driving Host Metabolic Reprogramming via the Tryptophan-Kynurenine-Retinol Pathway

Background & Aims: Alcoholic liver disease (ALD) is a major public health concern. Gut dysbiosis plays a critical role in its pathogenesis, yet the specific microbial and functional shifts driving ALD progression require further elucidation. This study aims to characterize these alterations a...

2026-01-10 | MTBLS13649 | MetaboLights
MetabolomicsEnterotoxigenic Bacteroides fragilis Exacerbates Alcoholic Liver Disease by Driving Host Metabolic Reprogramming via the Tryptophan-Kynurenine-Retinol Pathway

Background & Aims: Alcoholic liver disease (ALD) is a major public health concern. Gut dysbiosis plays a critical role in its pathogenesis, yet the specific microbial and functional shifts driving ALD progression require further elucidation. This study aims to characterize these alterations a...

2026-01-10 | MTBLS13650 | MetaboLights
MetabolomicsCroquemort elicits activation of the immune deficiency pathway in ticks
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain e...
2023-04-27 | MTBLS686 | MetaboLights
ProteomicsRecombinant Protein Spectral Library (rPSL) DIA-MS Method Improves Identification and Quantification of Low-Abundance Cancer-Associated and Kynurenine Pathway Proteins
Data-independent acquisition mass spectrometry (DIA-MS) is a powerful tool for quantitative proteomics, but a well-constructed reference spectral library is crucial to optimize DIA analysis, particularly for low-abundance proteins. In this study, we evaluate the efficacy of a recombinant protein spe...
ORGANISM(S): Homo sapiens (Human) 
2025-05-15 | PXD061696 | Pride
Snap frozen tissues Rpsl Dia-ms Cancer- associated proteins Cell lysates Kynurenine pathway proteins Recombinant protein spectral library 
MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
UnknownPhysicochemical Characterization of Kynurenine Pathway Metabolites.
Not available
S-EPMC12108296 | biostudies-literature
UnknownImmunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma.
Not available
S-EPMC7017805 | biostudies-literature
UnknownSystemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy.
Not available
S-EPMC10188306 | biostudies-literature
UnknownThe Genetic Link between Parkinson's Disease and the Kynurenine Pathway Is Still Missing.
Not available
S-EPMC4346699 | biostudies-literature
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