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ProteomicsRobust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - 80 compound screen (HEK293T and Jurkat)
In this manuscript we describe our work on the development of a label-free chemoproteomics screening platform for cysteine reactive covalent fragments on a 96 well plate format. Within this workflow, we profile cysteine reactive fragments by competition with the hyper-reactive iodoacetamide desthiob...
ORGANISM(S): Homo sapiens (Human) 
2024-11-18 | PXD054127 | Pride
Chemoproteomics Data independant acquisition Label-free qauntification 
ProteomicsCsde1 binds transcripts involved in protein homeostasis and controls their expression in erythropoiesis
The RNA binding protein Csde1 (Cold shock domain protein e1) is strongly upregulated during erythropoiesis, but its expression is reduced in Diamond Blackfan Anemia (DBA). To understand the role of Csde1 in DBA, and the cellular pathways controlled by Csde1 in erythropoiesis, we identified the trans...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD006358 | Pride
Proteomics Csde1 Label-free qauntification Ibaq Rna-binding protein Erythropoiesis Translation 
ProteomicsData in support of Prenatal intra-amniotic lipopolysaccharide induces neonatal renal immune activation after preterm birth
Preterm birth is often predisposed by chorioamnionitis (CA) and CA affects the fetal gut and lungs via intra-amniotic (IA) inflammation, thus accentuating the proinflammatory effects of preterm birth. It is not known if IA inflammation also affects other perfusion-sensitive organs (e.g., kidneys) be...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-03-25 | PXD014619 | Pride
Gram-negative infection Proteomics Chorioamnionitis Intrauterine bacterial infection Acute kidney injury 
ProteomicsData in support of Inflammatory Profile of Glucocorticoid Responsive Polymyalgia Rheumatica Patients
Polymyalgia rheumatica (PMR) is a systemic inflammatory disorder with unknown etiology and overlapping symptoms with giant cell arthritis and rheumatoid arthritis (RA). The inflammatory pathogenesis in PMR remain poorly uncharacterized and biomarker studies very limited. The primary aim of this stud...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD016870 | Pride
Rheumatoid arthritis Proteomics Cell free dna Cytokines Polymyalgia rheumatica Biomarkers 
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