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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
MetabolomicsAlterations in gut microbiota composition, plasma lipids, and brain activity, suggest inter-connected pathways influencing malnutrition-associated cognitive and neurodevelopmental changes.

Malnutrition affects over 30 million children annually and has profound immediate and enduring repercussions, with nearly half of child deaths under five linked to malnutrition. Survivors face lasting consequences, including impaired neurocognitive development, leading to cognitive and behavioura...

2024-11-27 | MTBLS10066 | MetaboLights
UnknownStand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.
Not available
S-EPMC3986383 | biostudies-literature
ProteomicsTranscriptomic and Proteomic Response of HC-04 to hepatocyte growth factor (HGF)
The routine study of human malaria liver-stage biology in vitro is hampered by low infection efficiency of human hepatocellular carcinoma (HCC) lines (<0.1%), poor understanding of steady-state HCC biology, and lack of appropriate tools for trace sample analysis. HC-04 is the only HCC that supports ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079959 | MassIVE
ProteomicsProteomic Atlas of the Human Brain in Alzheimer’s Disease
Here we provide a proteomic resource comprising nine functionally distinct sections from three individuals clinically diagnosed with Alzheimer's disease, across a spectrum of disease progression. Using state-of-the-art mass spectrometry, we identify a core brain proteome that exhibits only small var...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088398 | MassIVE
UnknownIonically crosslinked biohybrid gelatin-based hydrogels for 3D cell culture.
Not available
S-EPMC12267368 | biostudies-literature
UnknownGNUV201, a novel human/mouse cross-reactive and low pH-selective anti-PD-1 monoclonal antibody for cancer immunotherapy.
Not available
S-EPMC11088064 | biostudies-literature
ProteomicsUbiquitylome analysis of Arabidopsis roots.
Ubiquitylome analysis of Arabidopsis roots. 10 day old Arabidopsis roots were treated with mock, DMSO, or bortezomib for 3 hours. Root tissue was processed using the phenol-FASP method described in https://doi.org/10.1002/pmic.201800220. Ubiquitin remnant peptides were enriched using an anti-diglyci...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
MSV000086156 | MassIVE
ProteomicsThe proteome landscape of extracellular vesicles from prostate cancer cell lines
Proteome of extracellular vesicles (EVs) collected from prostate cancer cell lines - LNCaP, 22RV1, LNCaP 95, C4-2, DU145, PC3, NCI-H660, LASCPC-01, EF1.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-25 | MSV000096519 | MassIVE
UnknownSpike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy.
Not available
S-EPMC10473571 | biostudies-literature
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