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The highly conserved Dbf4-Dependent Kinase (DDK) plays a pivotal role in the nucleus during S phase, where it directly phosphorylates the replicative helicase, the minichromosome maintenance (MCM) complex. This leads to the initiation of chromosome replication. However, aside from the MCM complex, f...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-04-06 | PXD053426 | Pride
Cell cycle transitions are regulated by a number of coordinating signaling events. The ubiquitin-proteasome system is an important part of this cell cycle signaling. Cyclin F, a substrate adapter for the SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase, is an important regulator of cell cycle progression. ...
ORGANISM(S): Homo Sapiens (human) 
Intracellular Salmonella resides and multiplies in cholesterol-rich specialized compartment called Salmonella-containing vacuoles (SCVs) and avoids fusion with acidic lysosomes. Given, lysosomes are primary organelle that redistributes LDL derived cholesterol to other organelles; we questioned how l...
ORGANISM(S): Homo sapiens (Human) 
2024-10-28 | PXD055151 | Pride
Rett Syndrome (RTT), a severe neurological disorder caused by loss-of-function mutations in the X-linked Mecp2 gene, results in profound life-long neurological dysfunction. RTT patients live a normal initial life until 12-18 months of age following which, a progressive accumulation of a wide range o...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-05 | PXD065165 | Pride
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