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ProteomicsFrom LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver pathology worldwide, closely associated with obesity and metabolic disorders. Increasing evidence suggests that macrophages play a crucial role in the development of MASLD. Several human studies have shown an inver...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-01 | PXD056343 | Pride
Mouse Timstof pro 2 
UnknownLysosomal Acid Lipase Deficiency in 23 Spanish Patients: High Frequency of the Novel c.966+2T>G Mutation in Wolman Disease.
Not available
S-EPMC5740053 | biostudies-literature
ProteomicsRegional differences in the small intestinal proteome of control mice and of mice lacking lysosomal acid lipase
Background: Despite recent studies investigating the involvement of single cells in regional differences of the small intestine (SI), the metabolic contribution of the duodenum, jejunum, and ileum to the overall intestinal metabolism is still unclear. Basic procedures and main findings: Using an unt...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-20 | PXD048378 | Pride
Metabolism Proteomics Lal Small intestine Macrophages 
TranscriptomicsTranscription profiling of Streptomyces coelicolor wild type and delta0877 and delta7173 mutant strains
Gene expression analysis of S. coelicolor M145 wild type strain, and mutants delta0877 and delta 7173. RNA samples were extracted from 48 h culture samples during growth in flasks in defined mineral medium MG supplemented with 5% of yeast extract. Cy5 labelled genomic DNA was used as the common ref...
ORGANISM(S): Streptomyces coelicolor 
2009-04-17 | E-MEXP-2132 | biostudies-arrayexpress
UnknownImpact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration.
Not available
S-EPMC10209539 | biostudies-literature
TranscriptomicsMicroarray analysis of normal and abnormal chick myocardial development
The goal of this study was to determine developmental differences in gene expression between left and right ventricle, and to assess the differential effect of altered hemodynamic loading on left and right ventricle. Chick ventricles from different developmental stages were isolated for assessment o...
ORGANISM(S): Gallus gallus 
2012-12-28 | E-GEOD-37070 | biostudies-arrayexpress
ProteomicsComparative Proteomic profiling of the rostral band of LAL muscle from SMA mice and litter mate controls
Mouse sample preparation: 'Severe' SMA mice (Smn-/-;SMN2+/+) and wild-type (Smn+/+;SMN2+/+) littermates at postnatal day 5 (P5) were sacrificed by chilling on ice and decapitation. Levator auris longus (LAL, from the back of the neck) muscles were dissected in oxygenated mammalian physiological s...
ORGANISM(S): Mus musculus (Mouse) 
2013-10-09 | PXD000488 | Pride
Mouse lal muscle sma ltq orbitrap xl 
ProteomicsLanifibranor reduces inflammation and improves dyslipidemia in lysosomal acid lipase-deficient mice
Background & Aims Recent studies showed that patients suffering from lysosomal acid lipase-deficiency (LAL-D) benefit tremendously from enzyme replacement therapy (ERT), however, the outcomes on liver histology in treated patients were inconsistent. The promising results of the pan-PPAR agonist lani...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-12 | PXD047957 | Pride
Pan-ppar agonist Proteomics Lipid metabolism Lysosomal acid lipase deficiency Liver inflammation Plasma lipoproteins Lanifibranor 
UnknownShine & Lal index as a predictor for early detection of β-thalassemia carriers in a limited resource area in Bandung, Indonesia.
Not available
S-EPMC6688316 | biostudies-literature
ProteomicsLoss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice
Objective: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is limited. We hypothesized that LAL may play an impor...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD045665 | Pride
Muscle proteomics Lal Lal deficiency Energy metabolism Lal-deficient mouse 
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