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ProteomicsRepurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment
The myeloma bone marrow microenvironment drives proliferation of malignant plasma cells and promotes resistance to therapy. Interleukin-6 (IL-6) and downstream JAK/STAT signaling are thought to be central components of these microenvironment-induced phenotypes. In a prior drug repurposing screen, we...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006581 | Pride
Lc-msms Lfq Myeloma Bone marrow microenvironment Tofacitinib Human 
TranscriptomicsDiscovery and validation of a novel expression signature for recurrence in high-risk bladder cancer post-cystectomy
Purpose: Selecting muscle-invasive bladder cancer patients for adjuvant therapy is currently based on clinical variables with limited power. We hypothesized that genomic-based signatures can outperform clinical models to identify patients at higher risk. Method:Transcriptome-wide expression profiles...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-57933 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and QTL mapping of 60 mice from an F2 sample segregating for diabetes to generate expression trait correlations and expression quantitative trait locus mapping.
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts. To map gene regulatory pathways, we used microarray-derived gene expression measurements in 60 individuals of an F2 sample segregat...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3330 | biostudies-arrayexpress
ProteomicsIL-36 is a hallmark of Netherton syndrome with type I IFN, Th2 and Th9 responses distinguishing its dual clinical manifestations
Netherton syndrome (NS) is a rare recessive skin disorder caused by loss-of-function mutations in the gene SPINK5 encoding the protease inhibitor LEKTI. NS patients suffer from a severe skin barrier defect, display inflammatory skin lesions and superficial scaling with atopic manifestations. They ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-18 | MSV000086716 | MassIVE
TranscriptomicsValidation of a genomic classifier that predicts metastasis following radical prostatectomy in at risk patient population
Purpose: Patients with locally advanced prostate cancer after radical prostatectomy are candidates for secondary therapy. However, this higher risk population is heterogeneous. Many cases do not metastasize even when conservatively managed. Given the limited specificity of pathological features to p...
ORGANISM(S): Homo sapiens 
2014-11-13 | E-GEOD-62116 | biostudies-arrayexpress
TranscriptomicsSubcellular expression profiling of the growth cones of retinal ganglion cells (RGC)
Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in developing axons yet little is known about their subcellular distribution or, specifically, which transcripts are in growth cones. Laser capture microdissection (LCM) was used...
ORGANISM(S): Xenopus laevis 
2010-11-23 | E-GEOD-25166 | biostudies-arrayexpress
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
TranscriptomicsGlobal transcriptome analysis reveals differences between embryonic and adult dorsal root ganglion axonal mRNAs that are implicated in axonal growth and pain
Local protein synthesis in sensory neuron axons is necessary for axonal regeneration with the efficiency of regeneration decreasing with age. Because the full repertoire of transcripts in embryonic and adult rat sensory axons is unknown we asked how the pool of mRNAs dynamically changes during age...
ORGANISM(S): Rattus norvegicus 
2010-11-23 | E-GEOD-22638 | biostudies-arrayexpress
Proteomics,MultiomicsA draft map of the human proteome
The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here, we report a draft map of the human proteome based on high resolution Fouri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-16 | MSV000079514 | MassIVE
TranscriptomicsRole of Blimp-1 in programing Th effector cells into IL-10 producers
Gene expression profiling on IL-10-secreting and non-secreting murine Th1 cells, stimulated in the presence or absence of the Notch ligand Delta-like 4 (Dll4), was performed to identify transcription factors co-expressed with IL-10. Primary naM-CM-/ve T helper cells were isolated from lymph nodes an...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-57417 | biostudies-arrayexpress
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