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MetabolomicsMetabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry
Myelin is a natural and dynamic multilamellar membrane structure that continues to be of significant biological and neurological interest, especially with respect to its biosynthesis and assembly during its normal formation and maintenance, and pathological breakdown. To explore the usefulness of ne...
2024-09-27 | MTBLS4717 | MetaboLights
UnknownClinical safety and efficacy of a hydrophilic acrylic intraocular lens in a real-world population: a 1-year follow-up retro-prospective study.
Not available
S-EPMC7291478 | biostudies-literature
ProteomicsA Stat6/Pten axis links cold exposure with T cell tolerance in adipose tissue
Obesity and type-2 diabetes are associated with tissue-inflammation and metabolic defects in fat depots. Foxp3+regulatory T(Treg) cells mediate T-cell tolerance, thereby controlling tissue inflammation. However, the molecular underpinnings how environmental stimuli interlink T-cell tolerance with ad...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-11 | PXD004671 | Pride
T cell tolerance Foxp3 Cold exposure 
ProteomicsA novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells
Here we perform a phenotypic screen and identified novel compounds that can promote differentiation in several AML cell lines. Lead compounds are able to decrease tumour burden and increase survival in vivo. Using multiple complementary target deconvolution approaches (including chemoproteomics), th...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD022038 | Pride
Aml Tubulin Differentiation 
MetabolomicsTetrandrine regulates NAADP-mediated calcium signalling 1 through a novel LIMP-2-dependent, sphingosine-mediated mechanism.
Tetrandrine (Tet) is an highly potent inhibitor of Ebola virus replication by blocking NAADP51 dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
2025-05-23 | MTBLS12492 | MetaboLights
UnknownA Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function.
Not available
S-EPMC5627977 | biostudies-literature
TranscriptomicsVIA of EM CD8 T cells in vaccinated monkeys
The goal of an effective AIDS vaccine is to generate immunity that will prevent HIV-1 acquisition. Despite limited progress towards this goal, renewed optimism has followed the recent success of the RV144 vaccine trial in Thailand. However, the lack of complete protection in this trial suggests th...
ORGANISM(S): Macaca mulatta 
2012-06-14 | E-GEOD-35628 | biostudies-arrayexpress
Unknown<i>APOE</i> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease.
Not available
S-EPMC12083631 | biostudies-literature
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