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TranscriptomicsHCT116 cells isogenic for p53 expression upon treatment with actinomycin D and nutlin-3
HCT116 wild type cells express p53. The isogenic HCT116 p53KO cells have the p53 gene knocked out. Cells were treated for 16 hours. Dosages for actinomycin D treatment was 1 nM, 10 nM, and 100 nM. Dosage for nutlin-3 was 4 uM. Keywords: dose response Measuring the gene expression profile of the is...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-12459 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing identifies discrete classes of box C/D snoRNAs featuring different ends and RNA binding protein dependency
The paired-end next-generation sequencing of all small RNAs of less than 200 nucleotides in length from four different human cell lines (SKOV3ip1, MCF-7, BJ-Tielf, INOF) allowed us to determine the exact sequence(s) and variations of human box C/D snoRNAs (small nucleolar RNAs), revealing processing...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55946 | biostudies-arrayexpress
TranscriptomicsTranscriptome dynamics of developing photoreceptors in 3-D retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks
To define molecular mechanisms underlying rod and cone differentiation, we generated H9 human embryonic stem cell line carrying a GFP reporter that is controlled by the promoter of cone-rod homeobox (CRX) gene, the first known marker of post-mitotic photoreceptor precursors. CRXp-GFP reporter in H9 ...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-67645 | biostudies-arrayexpress
UnknownVitamin D status in post-medieval Northern England: Insights from dental histology and enamel peptide analysis at Coach Lane, North Shields (AD 1711-1857).
Not available
S-EPMC10830048 | biostudies-literature
MetabolomicsGNPS - Lomaiviticin A C D E - purified
LCMS run of LC-purified lomaiviticins A, C, D & E - Reference: Kersten, R.D., Lane, A.L., Nett, M., Richter, T.K., Duggan, B.M., Dorrestein, P.C., Moore, B.S. Bioactivity-Guided Genome Mining Reveals the Lomaiviticin Biosynthetic Gene Cluster in Salinispora tropica. Chembiochem 14, 955-962 (2013).
ORGANISM(S): Salinispora Tropica Cnb440 
2014-05-22 | MSV000078664 | GNPS
UnknownHypovitaminosis D in patients scheduled to undergo orthopaedic surgery: a single-center analysis.
Not available
S-EPMC2945929 | biostudies-literature
ProteomicsQuantitative analysis to the subcellular proteome in response to cathepsin D knockdown in HeLa cells
Cathepsin D is reportedly to be closely associated with tumor development, migration and invasion, but its pathological mechanism is not fully elucidated. We aimed to evaluate phenotypic changes and molecular events in response to cathepsin D knockdown. Lowering endogenous cathepsin D abundance (CR)...
ORGANISM(S): Homo sapiens (Human) 
2015-12-17 | PXD002844 | Pride
Cytosol Lysosome Silac Nucleus Subcellular fractionation 
UnknownVitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients.
Not available
S-EPMC8903333 | biostudies-literature
TranscriptomicsThe Genetic Basis of Rapidly Evolving Male Genital Morphology in Drosophila
Deep sequencing of total RNA extracted from the genital discs of males for each of the following strains : Drosophila sechellia, Drosophila mauritiana, hybrid introgression line 3Q1(A) and hybrid introgression line Q1(A) Analysis of poly(A)+ RNA for three independent biological replicates of sequenc...
ORGANISM(S): Drosophila sechellia 
2011-07-22 | E-GEOD-28663 | biostudies-arrayexpress
Genomics1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium Regulating Components (ChIP-seq)
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays an integral role in calcium homeostasis in higher organisms through its actions in the intestine, kidney and skeleton. Interestingly, while several intestinal genes are known to play a contributory role in calcium homeostasis, the entire caste of key comp...
ORGANISM(S): Mus musculus 
2015-06-03 | E-GEOD-69179 | biostudies-arrayexpress
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