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TranscriptomicsTh single cell RNA-Seq
Th2 cells regulate helminth infections, allergic disorders, tumor immunity and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2-signaling molecules. While steroids are known to be immunoregulators, de novo steroid production from immune cells has not been previo...
ORGANISM(S): Mus musculus 
2014-04-25 | E-MTAB-2512 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of FLAG-5MP complexes
FLAG-tagged 5MP (h5MP1/BZW2 from human and 5MP/Kra from fly) was ectopically expressed in relevant host cells (HEK293T for human and S2 for fly) by transient transfection, and one-step affinity-purified by anti-FLAG affinity resin.The one-step affinity purification products were resolved by SDS-PAGE...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2021-05-27 | PXD026284 | JPOST Repository
TranscriptomicsExpression of MERTK based on Multiple Sclerosis (MS) risk haplotype
Whole transcriptome RNA-seq analysis to measure group-wise RNA expression level of the MERTK gene in 3 healthy controls (known to be homozygous non-risk haplotype at MERTK gene locus) and to compare this to the group-wise RNA expression level of the MERTK gene in 5 Multiple Sclerosis-affected (MS-af...
ORGANISM(S): Homo sapiens 
2016-02-06 | E-GEOD-77598 | biostudies-arrayexpress
GenomicsApplication of Microdroplet PCR for Large-Scale Targeted Bisulfite Sequencing
Cytosine methylation of DNA CpG dinucleotides in gene promoters is an epigenetic modification that regulates gene transcription. While many methods exist to interrogate methylation states, no current methods offer large-scale, targeted, single CpG resolution. We report an approach combining bisulf...
ORGANISM(S): Homo sapiens 
2011-06-25 | E-GEOD-30179 | biostudies-arrayexpress
ProteomicsTgfbr2 in dental pulp cells guides neurite outgrowth in developing teeth
Transforming growth factor (TGF) plays an important role in tooth morphogenesis and mineralization. During postnatal development, the dental pulp (DP) mesenchyme secretes neurotrophic factors that guide trigeminal nerve fibers into and throughout the DP. This process is tightly linked with dentin f...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-04 | PXD031046 | Pride
Dental pulp Neurotrophins Neurite outgrowth Tgfbeta signaling Trigeminal Tooth development Sensory innervation Semaphorins Tgfbeta 
GenomicsDefining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation [Bisulfite-Seq]
Memory T cells are primed for rapid responses to antigen; however, the molecular mechanisms responsible for priming remain incompletely defined. CpG methylation in promoters is an epigenetic modification, which regulates gene transcription. Using targeted bisulfite sequencing, we examined methylatio...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-59858 | biostudies-arrayexpress
UnknownA Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial.
Not available
S-EPMC5728028 | biostudies-literature
TranscriptomicsThe long non-coding RNA Paupar regulates the expression of both local and distal genes [CHART-seq]
Although some long noncoding RNAs (lncRNAs) have been shown to regulate gene expression in cis, it remains unclear whether lncRNAs can directly regulate transcription in trans by interacting with chromatin genome-wide independently of their sites of synthesis. Here, we describe the genomically local...
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-52570 | biostudies-arrayexpress
TranscriptomicsPromoter H3K4 methylation reveals the dynamic reinforcement of activation-induced pathways in human CD4 T cells with differential kinetics in naïve and memory cells (RNA-Seq)
The epigenetic determinants driving the rapid responses of memory CD4 T cells to antigen are currently an area of active research. While much has been done to characterize various Th subsets and their associated genome-wide epigenetic patterns, the dynamics of histone modifications during CD4 T cel...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-73213 | biostudies-arrayexpress
UnknownWhole Exome Screening Identifies Novel and Recurrent WISP3 Mutations Causing Progressive Pseudorheumatoid Dysplasia in Jammu and Kashmir-India.
Not available
S-EPMC4904372 | biostudies-literature
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