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TranscriptomicsAn ABA response regulator unique to basal land plants required for the acquisition of desiccation tolerance
Purpose: The plant hormone abscisic acid (ABA) coordinates responses leading to desiccation tolerance in all land plants. RNA-seq was employed to obtain differential expression data in response to ABA, dehydration and mannitol treatments in wild-type tissue. This was compared against the targeted ge...
ORGANISM(S): Physcomitrella patens 
2016-07-25 | E-GEOD-72583 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spleens from dual specificity phosphatase-1 (DUSP1) deficient and wild type mice to demonstrate a specific regulatory role of DUSP1 on a subset of LPS-induced genes that control the outcome of endotoxin shock.
Activation of the Mitogen activated protein kinase (MAPK) cascade following Toll-like receptor (TLR) stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we iden...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-3565 | biostudies-arrayexpress
UnknownPragmatic trial evaluating the effectiveness of a patient navigator to decrease emergency room utilisation in transition age youth with chronic conditions: the Transition Navigator Trial protocol.
Not available
S-EPMC6924868 | biostudies-literature
ProteomicsThe CD24 receptor induces changes to the surface protein composition of B cell microvesicles with variable effects on their RNA and protein cargo
The CD24 cell surface receptor promotes apoptosis in developing B cells, and we recently found that it induces B cells to release plasma membrane-derived, CD24-bearing microvesicles (MVs). Here we have performed a systematic characterization of B cell MVs released from WEHI-231 B lymphoma cells in r...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-01 | PXD005919 | Pride
Cd24 Microvesicle Extracellular microvesicles Proteomics B lymphocyte Mitochondria 
TranscriptomicsEmergence of a developmental stage-dependent human liver disease signature demonstrated by directed differentiation of alpha-1 antitrypsin deficient iPS cells [HumanMethylation450]
We monitored 9 pluripotent stem cell lines across three time points of hepatic directed differentiation, representing 3 developmental stages: undifferentiated (T0), definitive endoderm (T5), and early hepatocyte (T24). ESCs (n=3) and patient-derived normal (n=3) or PiZZ (n=3) iPSCs were analyzed in ...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-66077 | biostudies-arrayexpress
TranscriptomicsEmergence of a developmental stage-dependent human liver disease signature demonstrated by directed differentiation of alpha-1 antitrypsin deficient iPS cells [HuGene-1_0-st]
We monitored 9 pluripotent stem cell lines across three time points of hepatic directed differentiation, representing 3 developmental stages: undifferentiated (T0), definitive endoderm (T5), and early hepatocyte (T24). ESCs (n=3) and patient-derived normal (n=3) or PiZZ (n=3) iPSCs were analyzed in ...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-66076 | biostudies-arrayexpress
TranscriptomicsEmergence of a developmental stage-dependent human liver disease signature demonstrated by directed differentiation of alpha-1 antitrypsin deficient iPS cells [miRNA-2_0]
We monitored 9 pluripotent stem cell lines across three time points of hepatic directed differentiation, representing 3 developmental stages: undifferentiated (T0), definitive endoderm (T5), and early hepatocyte (T24). ESCs (n=3) and patient-derived normal (n=3) or PiZZ (n=3) iPSCs were analyzed in ...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-66075 | biostudies-arrayexpress
UnknownHealth care stakeholder perspectives regarding the role of a patient navigator during transition to adult care.
Not available
S-EPMC6580652 | biostudies-literature
UnknownNon-Metastatic Esophageal Adenocarcinoma: Circulating Tumor Cells in the Course of Multimodal Tumor Treatment.
Not available
S-EPMC6468610 | biostudies-literature
ProteomicsLipid nanotubes unmask neutrophils for complement attack
Neutrophils, critical components of innate immunity, undergo significant morphological changes during phagocytosis. In this study, we demonstrate that neutrophils exposed to shear stress generate lipid nanotubes (NTs) with a unique composition. Compared to the proteome of whole neutrophils, NTs nota...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD064111 | Pride
Complement system Shear stress Extracellular vesicles Neutrophils Polytrauma Vasculitis 
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