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TranscriptomicsGene expression profile of LAPC4 stimulated by 5α-Abi
LAPC4 cells were starved for 2 days and stimulated with 1µM 5α-Abi or 0.1nM DHT. Gene expression profiles are detected to determine the effect of 5a-Abi on prostate cancer cell line. LAPC4 cells were starved for 2 days with phenol red-free and serum free-medium and stimulated with 1µM 5α-Abi or...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-75387 | biostudies-arrayexpress
TranscriptomicsGene expression profile of LAPC4 stimulated by 5α-Abi
LAPC4 cells were starved for 2 days and stimulated with 1µM 5α-Abi or 0.1nM DHT. Gene expression profiles are detected to determine the effect of 5a-Abi on prostate cancer cell line.
ORGANISM(S): Homo sapiens 
2016-03-01 | GSE75387 | GEO
ProteomicsAlkyne-probe pull-down in LAPC4-CR cells
LAPC4-CR cells were treated with alkyne-probe or DMSO for 2 h in triplicate, lysed and conjugated with biotin-picolyl-azide. Biotinylated proteins were pulled down with neutravidin agarose. After the pulldown, the neutravidin agarose beads were treated with trypsin, and the tryptic peptides were lab...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-30 | MSV000093542 | MassIVE
TranscriptomicsTranscription profiling of human prostate cancer cells after I?-TrCP inhibition and androgen ablation in prostate cancer cells
We examined gene expression of LAPC4 cells after knocking down β-TrCP, androgen ablation, or the combined treatments compared to non treated cells. Experiment Overall Design: Using lentiviral vectors, we stably infected LAPC4 cells with specific shRNA targeted for both β-TrCP isoforms (i.e. 1 and ...
ORGANISM(S): Homo sapiens 
2009-11-28 | E-GEOD-19141 | biostudies-arrayexpress
ProteomicsCDK4/6 inhibitor resistance in prostate cancer
CDK4/6 kinase inhibitors have shown great promise in clinical trials in various cancer types and have recently entered clinical trial for advanced prostate cancer. Although patients are expected to respond well to this class of drugs, development of resistance in some patients is anticipated. To pre...
ORGANISM(S): Homo sapiens (Human) 
2018-05-16 | PXD006561 | Pride
Palbociclib Lapc4 Ribociclib Cdk4/6 Prostate cancer Lncap 
GenomicsHomo sapiens
Gene expression profile of LAPC4 stimulated by 5α-Abi
PRJNA304040 | ENA
GenomicsRNA-Seq of LAPC4 human prostate cancer cells with knockdown of MAP3K7 and CHD1
RNA-Seq of LAPC4 human prostate cancer cells with knockdown of MAP3K7 and CHD1
PRJNA713351 | ENA
TranscriptomicsTranscriptional profiles induced by either androgen depletion or androgen receptor knockdown
Although the vital role of the androgen receptor (AR) has been well demonstrated in primary prostate cancers, its role in the androgen-insensitive prostate cancers still remains unclear. Here, we used a small hairpin RNA approach to directly assess AR activity in prostate cancer cells. Reduction of ...
ORGANISM(S): Homo sapiens 
2007-08-08 | E-GEOD-7585 | biostudies-arrayexpress
TranscriptomicsExpression profile after β-TrCP inhibition and androgen ablation in prostate cancer cells
We examined gene expression of LAPC4 cells after knocking down β-TrCP, androgen ablation, or the combined treatments compared to non treated cells.
ORGANISM(S): Homo sapiens 
2009-11-24 | GSE19141 | GEO
TranscriptomicsPhenotypic characterization of two novel cell line models of castration resistant prostate cancer
Purpose: Resistance to androgen deprivation therapies is a major driver of mortality in advanced prostate cancer. Therefore, there is a need to develop new pre-clinical models that allow the investigation of resistance mechanisms and the assessment of drugs for the treatment of castration resistant ...
ORGANISM(S): Homo sapiens 
2021-06-27 | GSE178963 | GEO
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