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TranscriptomicsFunctional tissue specific MSC in lung-transplanted patients with and without bronchiolitis obliterans syndrome (BOS) - a potential source for cell-therapy?
Background: Mesenchymal stromal cells (MSC) have been proposed as a future cell based therapy for lung diseases like bronchiolitis obliterans syndrome (BOS). Theoretically, it might be beneficial to use lung resident MSC already adapted to the pulmonary environment. We therefore aimed to compare lun...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-74163 | biostudies-arrayexpress
ProteomicsQuantifying extracellular matrix turnover in human lung scaffold cultures
Tissue engeneering using biological scaffolds are a promising technique for solving the shortage of donor organs for patients suffering of end stage organ faliure. We introduced stable isotope labeling with amino acids in a tissue culture setting, which enabeled us to distinguish between the biologi...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD007995 | Pride
Human Ecm Lung Silac 
ProteomicsAlveolar epithelial cells are competent producers of interstitial extracellular matrix with disease relevant plasticity in a human in vitro 3D model
The structure of alveoli is critical for proper lung function, the extracellular matrix (ECM) that forms these delicate structures need to be maintained throughout life, when this fails, patients suffer from conditions such as emphysema or lung fibrosis. The alveolar walls are lined by alveolar epit...
ORGANISM(S): Homo sapiens (Human) 
2023-06-29 | PXD034531 | Pride
Human Ecm Ipf Copd Lung Remodeling Alveolar epithelium 
TranscriptomicsRole of microRNAs and microRNA machinery in the pathogenesis of Diffuse large B-cell Lymphomas
We performed miRNA expression profiling in a series of de novo DLBCLs, transformed DLBCLs and non-neoplastic lymph nodes using a microarray approach. Significant differentially expressed miRNAs among groups were identified using SAM analysis. Agilent microarray platform containing 470 miRNAs was us...
ORGANISM(S): Homo sapiens 
2014-01-27 | E-GEOD-42906 | biostudies-arrayexpress
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