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TranscriptomicsDose-dependent dual roles of PDGF-BB–PDGFR-? in vascular remodeling and opposing effects of anti-PDGF drug-induced metastasis
Anti-PDGF agents are routinely used as a key component in front-line therapy for the treatment of various cancers. However, molecular mechanisms underlying their impact on vascular remodeling in relation to the dose issue remain poorly understood. Here we show that in high PDGF-BB-producing tumors, ...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-46564 | biostudies-arrayexpress
UnknownIs an improvement in anaemia and iron levels associated with the risk of early postpartum depression? A cohort study from Lagos, Nigeria.
Not available
S-EPMC11869588 | biostudies-literature
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
UnknownSensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr gene.
Not available
S-EPMC2683749 | biostudies-literature
TranscriptomicsCharacterization of the starvation response in the Arabidopsis dcl1-9 mutant
The SnRK1 protein kinase, the plant ortholog of mammalian AMPK and yeast Snf1, is activated by the energy depletion caused by adverse environmental conditions. Upon activation, SnRK1 triggers extensive transcriptional changes to restore homeostasis and promote stress tolerance and survival partly th...
ORGANISM(S): Arabidopsis thaliana 
2013-07-15 | E-GEOD-46713 | biostudies-arrayexpress
ProteomicsA proteomic approach to identify alterations in the SUMO network during controlled mechanical ventilation in rat diaphragm muscle
SUMOylation is a key post-translational modification that regulates crucial cellular functions and pathological processes. It has emerged as a fundamental route that may drive different steps of human diseases. Indeed, alteration in expression or activity of one of the different SUMO pathway compone...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-04-05 | PXD006085 | Pride
Mechanical ventilation Sumo Sumo biomarkers Diaphragm Skeletal muscle 
UnknownEffect of vitamin D and inhaled corticosteroid treatment on lung function in children.
Not available
S-EPMC3480528 | biostudies-literature
TranscriptomicsRNA-seq of human and mouse stem-cell derived neurons and mouse primary cortical neurons after KCl-induced membrane depolarization against controls.
This experiment comprises RNA-seq data used to study evolutionary differences between humans and mice in neuronal activity-dependent transcriptional responses. Activity-dependent transcriptional responses in developing human stem cell-derived cortical neurons were compared with those induced in deve...
ORGANISM(S): Mus musculus 
2017-02-16 | E-MTAB-5489 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression signatures of imatinib-treated and non-treated gastrointestinal stromal tumors
We performed microRNA expression profiling in a series of fresh-frozen neoadjuvantly imatinib-treated and non-treated gastrointestinal stromal tumors (GIST), using a microarray approach. Significant differentially expressed microRNAs among imatinib-treated and non-treated groups were identified usi...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-63159 | biostudies-arrayexpress
UnknownAbnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.
Not available
S-EPMC6237216 | biostudies-literature
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