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TranscriptomicsGene expression profile in the diaphragm following contractile inactivity during thoracic surgery
Recent work revealed the development of marked diaphragm muscle fiber weakness during two hours of thoracic surgery. This loss of muscle fiber function was not part of a generalized muscle weakness as function of the non-respiratory latissimus dorsi muscle was preserved. To disentangle the molecular...
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-30658 | biostudies-arrayexpress
TranscriptomicsNormal rat diaphragm vs sternohyoid
Normal young adult Sprague Dawley rats (male) 6 diaphragm muscle samples are compared with 6 sternohyoid muscle samples -- each sample is one muscle from one rat
ORGANISM(S): Rattus norvegicus 
2010-07-15 | E-GEOD-12282 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat treated with streptozotocin or buffer alone at age of 8 weeks, diaphragm muscle
8 week old rats injected with streptozotocin or buffer alone at age of 8 weeks, diaphragm muscle obtained at age of 12 weeks (thus animals were diabetic for 4 weeks) Experiment Overall Design: Three control rats (normal diaphragm #1, 2, 3) Experiment Overall Design: Three diabetic rats (diabetic dia...
ORGANISM(S): Rattus norvegicus 
2009-11-28 | E-GEOD-4653 | biostudies-arrayexpress
TranscriptomicsCells isolated from diaphragm of mdx mouse: satellite cells vs. PDGFRa+ cells
Transcriptional profiling of mouse skeletal muscle-derived cells comparing satellite cells with PDGFRa+ cells. Satellite cells and PDGFRa+ cells were directly isolated from diaphragm of dystrophic mdx mouse by FACS. Two-condition experiment, satellite cells vs. PDGFRa+ cells. Freshly isolated. One r...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-25258 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of rat diaphragm before and after acute cervical spinal cord injury
Male Sprague Dawley adult rats were subjected to a cervical hemisection at C2 (C2HS). Costal diaphragm (both ipsilesional and contralesional sides) were assessed under control conditions (sham surgery) and at 1 and 7 days post-C2HS. We used SA Biosciences Rat Skeletal Muscle Development and Disea...
ORGANISM(S): Rattus norvegicus 
2013-12-18 | E-GEOD-45021 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse diaphragm, comparison of wild type and mdx mice, 7 to 112 days
Determination of gene expression changes in diaphragm muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004.
ORGANISM(S): Mus musculus 
2007-10-05 | E-GEOD-1026 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of diaphragm muscles from alpha2-laminin (merosin)-deficient dy/dy dystrophic mice and wild type mice to study differential gene expression.
Laminin (merosin) deficient muscular dystrophy in dy/dy mouse diaphragm muscle, 8 weeks old Experiment Overall Design: 4 normal samples; 4 dystrophic samples; Each sample consists of muscle pooled from 3 mice, thus a total of 12 normal and 12 dystrophic mice were studied
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3252 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Diaphragm after Chronic Heart Failure_Males
Proteomic analysis of diaphragm tissue from rats subjected to chronic heart failure. Redox sensitive Cysteine residues from both adult and old diaphragm tissues examined
ORGANISM(S): Rattus norvegicus (Rat) 
2020-04-15 | PXD012500 | Pride
Heart failure Rat Diaphragm 
ProteomicsProteome of Young and Old Murine Diaphragm and Associaated Changes in Contractile Properties
Proteomic analysis of young and old murine diaphragm and associated changed in contractile aproperties. Redox sensitive Cysteine residues from both adult and old diaphragm tissues examined.
ORGANISM(S): Mus musculus (Mouse) 
2018-02-12 | PXD005014 | Pride
Mouse Diaphragm Redox 
ProteomicsA proteomic approach to identify alterations in the SUMO network during controlled mechanical ventilation in rat diaphragm muscle
SUMOylation is a key post-translational modification that regulates crucial cellular functions and pathological processes. It has emerged as a fundamental route that may drive different steps of human diseases. Indeed, alteration in expression or activity of one of the different SUMO pathway compone...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-04-05 | PXD006085 | Pride
Mechanical ventilation Sumo Sumo biomarkers Diaphragm Skeletal muscle 
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