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ProteomicsDYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant immunosuppressive and fibrotic tumor microenvironment (TME). Future therapeutic attempts therefore demand targeting of both compartments in order to be effective. We show here that Dual Specificity and Tyrosine...
ORGANISM(S): Mus Musculus 
2024-01-02 | MSV000093747 | MassIVE
TranscriptomicsTranscriptional changes in IMR32 cells upon ISX treatment
IMR32 neuroblastoma cells were treated with ISX, a novel GLI1 inducing HDAC-inhibitor
ORGANISM(S): Homo sapiens 
2021-04-28 | E-MTAB-10249 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes in MCF7 cells upon ISX treatment
MCF7 cells were treated with ISX, a novel GLI1 inducing HDAC-inhibitor
ORGANISM(S): Homo sapiens 
2021-04-28 | E-MTAB-10248 | biostudies-arrayexpress
TranscriptomicsMouse bone-marrow-derived macrophages treated with supernatant of DYRK1B-deletion / Wildtype mKpc4 cells
Mus musculus macrophages were derived from bone marrow, and treated with the supernatant of of DYRK1B-deletion (multiple clones) or Wildtype mKpc4 cells.
ORGANISM(S): Mus musculus 
2024-05-29 | E-MTAB-13668 | biostudies-arrayexpress
TranscriptomicsRNA-seq of murine CD4 T cells after pentanoate treatment compared to untreated control
To analyse the influence of pentanoate on the differentiation of naive CD4 T cells under Th17 inducing conditions, murine CD4 T cells were isolated from spleen and lymphnodes of FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice). The T cells were kept for 3 days under Th17 inducing condition...
ORGANISM(S): Mus musculus 
2019-01-15 | E-MTAB-6114 | biostudies-arrayexpress
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
TranscriptomicsRNAseq of tumor cell lines LNCaP and DU145 irradiated by photons or carbon ions
Since radiotherapy is the essential treatment of prostate cancer, this experiment aimed to elucidate the transcriptomic response of prostate cancer cells to irradiation by either conventional photons or alternatively carbon ions, focusing on DNA damage, DNA repair and androgen receptor signaling.
ORGANISM(S): Homo sapiens 
2025-07-07 | E-MTAB-14099 | biostudies-arrayexpress
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