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UnknownSurvival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab.
Not available
S-EPMC4811023 | biostudies-literature
TranscriptomicsExpression data from human sarcoma patient samples treated with either vehicle control or Nutlin-3a
This study has examined the molecular mechanisms underlying sensitivity of sarcomas to Nutlin-3a, a non-genotoxic activator of the p53 pathway. Human patient material was collected immediately following surgical resection, dissected into small pieces and ex planted onto gelatin sponges immersed in m...
ORGANISM(S): Homo sapiens 
2014-03-10 | E-GEOD-48296 | biostudies-arrayexpress
GenomicsWhole genome methylation profiling in developing and developed Zebrafish
DNA methylation is a dynamic process through which specific chromatin modifications can be stably transmitted from parent to daughter cells. A large body of work has suggested that DNA methylation influences gene expression by silencing gene promoters. However, these conclusions were drawn from data...
ORGANISM(S): Danio rerio 
2014-03-25 | E-GEOD-52110 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cell lines using a dene-resolution analysis method of DNA copy number variation using oligonucleotide expression microarrays
We present a novel method of using commercial oligonucleotide expression microarrays for aCGH, enabling DNA copy number measurements and expression profiles to be combined using the same platform. This method yields aCGH data from genomic DNA without complexity reduction at a median resolution of ap...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7364 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of high Arctic soil bacterial response to hydrocarbon pollution and bioremediation: genomic DNA
High Arctic soils have low nutrient availability, low moisture content and very low temperatures and, as such, they pose a particular problem in terms of hydrocarbon bioremediation. An in-depth knowledge of the microbiology involved in this process is likely to be crucial to understand and optimize ...
ORGANISM(S): Escherichia coli 
2010-05-15 | E-GEOD-17517 | biostudies-arrayexpress
UnknownPhylogenomics and genetic analysis of solvent-producing Clostridium species.
Not available
S-EPMC11063209 | biostudies-literature
TranscriptomicsDiet rapidly and reproducibly alters the human gut microbiome
Long-term dietary intake influences the structure and activity of the trillions of microorganisms residing in the human gut, but it remains unclear how rapidly and reproducibly the human gut microbiome responds to short-term macronutrient change. Here we show that the short-term consumption of diets...
ORGANISM(S): human gut metagenome 
2013-12-05 | E-GEOD-46761 | biostudies-arrayexpress
TranscriptomicsInhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis
Nonsense-mediated RNA decay (NMD) is regulated by a variety of cellular stresses. We expose U2OS cells to several stresses and assess RNA expression in the absence of transcription (i.e. stability). These studies identify transcripts that are stabilized by the physiological inhibition of NMD. U2OS ...
ORGANISM(S): Homo sapiens 
2011-07-08 | E-GEOD-30499 | biostudies-arrayexpress
UnknownDonepezil delays progression to AD in MCI subjects with depressive symptoms.
Not available
S-EPMC2697965 | biostudies-literature
GenomicsTRACERx: TRAcking non-small cell lung Cancer Evolution through therapy (Rx). Pilot Study. Multi-region sequencing of early-stage NSCLCs.
Deciphering the complexity of non-small cell lung cancer (NSCLC) evolutionary histories may elucidate the basis for its dismal outcome. We performed multi-region sequencing of early-stage NSCLCs. Spatial dissection revealed branched tumor evolution, with driver mutations occurring before and after s...
EGAS00001000809 | EGA
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