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ProteomicsIdentifying Layilin Interaction Partners
This project aimed to identify the ligand for the cell surface receptor and C-type lectin laylin, a surface receptor with unknown function.
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD027886 | Pride
T cell C-type lectin Collagen Layilin 
UnknownLayilin regulates Treg motility and suppressive capacity in skin.
Not available
S-EPMC12279370 | biostudies-literature
UnknownLayilin Anchors Regulatory T Cells in Skin.
Not available
S-EPMC8489406 | biostudies-literature
UnknownLayilin augments integrin activation to promote antitumor immunity.
Not available
S-EPMC7478725 | biostudies-literature
UnknownRole of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins.
Not available
S-EPMC11515419 | biostudies-literature
UnknownLayilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles.
Not available
S-EPMC2132847 | biostudies-literature
UnknownLayilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo.
Not available
S-EPMC5845474 | biostudies-literature
UnknownHyperglycemic environments directly compromise intestinal epithelial barrier function in an organoid model and hyaluronan (∼35 kDa) protects via a layilin dependent mechanism.
Not available
S-EPMC12327694 | biostudies-literature
TranscriptomicsRNAseq data from expanded human Treg isolated from healthy blood donor and crispr for target candidate or scramble
Regulatory T cells (Tregs) are essential for maintaining immune tolerance in both lymphoid and non-lymphoid tissues. We discovered that layilin, a C-type lectin receptor, is predominantly expressed on Tregs in skin.
ORGANISM(S): Homo sapiens 
2025-07-30 | GSE282563 | GEO
TranscriptomicsRNAseq data from mouse skin Treg isolated after imiquimod treatment
Regulatory T cells (Tregs) are essential for maintaining immune tolerance in both lymphoid and non-lymphoid tissues. We discovered that layilin, a C-type lectin receptor, is predominantly expressed on Tregs in skin.
ORGANISM(S): Mus musculus 
2025-07-30 | GSE282465 | GEO
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