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GenomicsCell-Specific Determinants of PPARg Function in Adipocytes and Macrophages
The nuclear receptor Peroxisome Proliferator Activator Receptor (PPAR ) is the target of antidiabetic thiazolidinedione drugs, which improve insulin resistance but have side-effects that limit widespread use. PPAR is required for adipocyte differentiation, but is also expressed in other cell type...
ORGANISM(S): Mus musculus 
2010-04-14 | E-GEOD-21314 | biostudies-arrayexpress
GenomicsDiurnal changes of HDAC3, Rev-erbα, NCoR and Pol II recruitment to the mouse liver genome and of H3K9Ac
We reported a diurnal changes in the recruitment of HDAC3, Rev-erbα, NCoR and Pol II to the mouse liver genome as well as H3K9 acetylation in vivo at ZT10 and ZT22. ChIP-Seq profiling of HDAC3, Rev-erbα, NCoR and Pol II binding and H3K9Ac in mouse liver harvested at 2 different times (ZT10 and ZT22)...
ORGANISM(S): Mus musculus 
2011-03-11 | E-GEOD-26345 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse liver depleted of HDAC3
Liver-specific depletion of HDAC3 leads to liver steatosis (fatty liver), suggesting disregulation of lipid metabolism. This is correlated with changes in lipid metabolic gene expression. Livers depleted of HDAC3 were removed from 12 week old male HDAC3 fl/fl mice (loxP sites flanking exon 4 to 7 of...
ORGANISM(S): Mus musculus 
2011-03-11 | E-GEOD-25937 | biostudies-arrayexpress
GenomicsPropagation of Adipogenic Signals through an Epigenomic Transition State
The transcriptional mechanisms by which temporary exposure to developmental signals instigates adipocyte differentiation are unknown. During early adipogenesis, we find transient enrichment of the glucocorticoid receptor (GR), CCAAT/enhancer binding protein b (CEBPb), p300, mediator subunit 1, and h...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-21898 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse heart deficient of HDAC3
Gene expression changes in the heart of MCH3-KO mouse (HDAC3 f/f, Muscle Creatine Kinase-Cre) versus control WT mouse (HDAC3 f/f). Histone deacetylases (HDACs) play important roles in cardiac development and function. We show here that mice deficient of HDAC3 in heart and skeletabl muscle are relati...
ORGANISM(S): Mus musculus 
2011-09-20 | E-GEOD-31251 | biostudies-arrayexpress
GenomicsMetabolic Transcription Factors Mediate Conserved Functions Largely via Species-Specific Binding Regions
The winged helix protein FOXA2 and the nuclear receptor PPARg are highly conserved, regionally-expressed transcription factors that regulate networks of genes controlling complex metabolic functions. Cistrome analysis for FOXA2 in mouse liver and PPARg in mouse adipocytes has previously produced co...
ORGANISM(S): Homo sapiens 
2011-04-06 | E-GEOD-25836 | biostudies-arrayexpress
GenomicsGenome-wide maps of TCF7L1 binding during early adipogenesis
Here we show through genome-wide binding studies that transcription factor 7-like 1 (TCF7L1) represses structure-related genes during adipogenesis. Intriguingly, TCF7L1 is induced in a cell contact-dependent manner by confluency in preadipocytes and is required for adipocyte differentiation by repre...
ORGANISM(S): Mus musculus 
2011-09-02 | E-GEOD-31867 | biostudies-arrayexpress
GenomicsEpigenome in brown and white adipose tissue
For comparative epigenomic analysis of brown fat and white fat in mice, H3K27ac and PolII ChIP-seq were performed in each depot. H3K27ac histone modification and PolII transcription profiles in mouse brown and white adipose tissues
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-63964 | biostudies-arrayexpress
TranscriptomicsThe Nuclear Receptor Rev-erb alpha Regulates Adipose Tissue-Specific FGF21 Signaling (Microarray)
To investigate the role of the transcriptional repressor Rev-erb alpha in epididymal white adipose tissue, we performed a microarray analysis of gene expression in the epididymal white adipose tissue of wildtype and Rev-erb alpha knock-out mice. Examination of the transcriptome in epididymal white a...
ORGANISM(S): Mus musculus 
2016-07-20 | E-GEOD-79164 | biostudies-arrayexpress
TranscriptomicsCircadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo
Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock.  We have determined the underlying mechanisms by measuring nascent RNA transcription around the clock in mouse liver. Unbiased ex...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-59460 | biostudies-arrayexpress
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