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ProteomicsSequence coverage by multiple reads in shotgun proteomics to validate single amino acid variants
Mass spectrometry-based shotgun proteomics is currently based on assigning matches between mass-spectra of protein fragments resulting from protease digestion and amino acid sequences predicted from nucleic acid sequences. At the same time, the method lacks reliability in identification of every sin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-07 | MSV000088536 | MassIVE
ProteomicsThe Role of Extracellular Spliceosomal snRNAs in Communication of Ovarian Cancer Cells
Exogenous signals from drug-stressed cancer cells accelerate the proliferation of neighboring tumor cells and promote them to acquire a more aggressive phenotype. We have recently found an exciting phenomenon: drug-stressed cancer cells secrete various components of the spliceosome: proteins and a n...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD027950 | Pride
Ovarian cancer Small nuclear rna Proteomics Spliceososme 
ProteomicsExome-based proteogenomics of HEK-293 human cell line: coding genomic variants identified at the level of shotgun proteome
Genomic and proteomic data were integrated into the proteogenomic workflow to identify coding genomic variants of Human Embryonic Kidney 293 (HEK-293) standard cell line at the proteome level. Shotgun proteome data published by Geiger et al (2012) and obtained in this work for HEK-293 were searched ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080712 | MassIVE
ProteomicsSILAC Strategy for Analysis of Proteins Released To the Extracellular Medium and Penetrated
Exogenous signals from drug-stressed cancer cells accelerate the proliferation of neighboring tumor cells and promote them to acquire a more aggressive phenotype. We have recently found an exciting phenomenon: drug-stressed cancer cells secrete various spliceosomal proteins. We have observed this ph...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD027948 | Pride
Ovarian cancer Silac Therapy-induced secretome Extracellular vesicles 
ProteomicsSubcellular Relocalization of Proteins in Response to Cisplatin-Induced DNA Damage
Cells regulate the intracellular localization of proteins to adapt to different environmental conditions including DNA damage, but this form of regulation has not been analyzed systematically. The aim of this study was to investigate the protein distribution between nucleus and cytoplasm in response...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD019642 | Pride
Ovarian cancer Subcellular proteomics Cisplatin 
ProteomicsCisplatin-Induced Changes in Proteomic Profiles of Ovarian Cancer Cell and Fibroblast Secretomes
Exogenous signals from drug-stressed cancer cells promote acquisition of a more aggressive phenotype of neighboring tumor cells. To identify extracellular signaling molecules that potentially contribute to the development of therapy resistance, we examined how cancer cell secretome changes in respon...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD019096 | Pride
Ovarian cancer Fibroblasts Therapy-induced secretome 
ProteomicsEffect of malignant ascites before and after therapy on the proteome of ovarian cancer cells
Ovarian cancer is characterized by transcoelomic metastasis into the peritoneal cavity. The peritoneal malignant ascites is enriched with ovarian cancer cells and a small amount of tumor-associated immune cells which create a unique microenvironment actively contributing to progression of the diseas...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD045647 | Pride
Ovarian cancer Chemoresistance Ascites 
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