Sort   by:  
 Page size 
UnknownGlucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.
Not available
S-EPMC1618362 | biostudies-literature
UnknownCD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance.
Not available
S-EPMC9975250 | biostudies-literature
UnknownActivation of naive CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling.
Not available
S-EPMC522036 | biostudies-literature
UnknownFusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.
Not available
S-EPMC8211700 | biostudies-literature
ProteomicsLCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice
LCK is an SRC-family kinase that mediates the initial steps in T-cell antigen receptor signaling and governs positive and negative selection during thymocyte development. While its developmental role is well established, its functions in peripheral T-cell responses remain poorly defined. Here, we in...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-25 | PXD082506 | Pride
Cytotoxic Fyn Lck Effector formation T cells T-cell receptor Signaling 
GenomicsRNA sequencing of PTCL-NOS
To further improve our understanding of the genetic landscape and biology of PTCL-NOS, we performed RNA-sequencing of 15 cases. We describe a recurrent FYN-TRAF3IP2 fusion transcript in PTCL-NOS and PTCL-TFH and a KHDRBS1-LCK fusion transcript in PTCL-NOS.
EGAS00001005015 | EGA
TranscriptomicsLCK-deficient CD8 T-cell show reduced proliferation but normal effector responses in vivo
The overall study investigated the role of LCK and FYN in peripheral CD8⁺ T-cell responses using adoptive transfers of LCK- or FYN-deficient monoclonal T cells into polyclonal hosts. To assess the role of LCK in T-cell differentiation in greater detail, we performed a single-cell transcriptomics stu...
ORGANISM(S): Mus musculus 
2025-08-15 | GSE304760 | GEO
TranscriptomicsTCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation
To systematically evaluate the effect of inhibition of Lck/Fyn kinase activity on the differentiation of TH17 and Treg cells.
ORGANISM(S): Mus musculus 
2024-01-31 | GSE229377 | GEO
TranscriptomicsLCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice [scRNA-seq]
LCK is an SRC-family kinase that mediates the initial steps in T-cell antigen receptor signaling and governs positive and negative selection during thymocyte development. While its developmental role is well established, its functions in peripheral T-cell responses remain poorly defined. Here, we in...
ORGANISM(S): Mus musculus 
2026-08-09 | GSE342586 | GEO
TranscriptomicsLCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice [Bulk RNA-seq]
LCK is an SRC-family kinase that mediates the initial steps in T-cell antigen receptor signaling and governs positive and negative selection during thymocyte development. While its developmental role is well established, its functions in peripheral T-cell responses remain poorly defined. Here, we in...
ORGANISM(S): Mus musculus 
2026-08-09 | GSE342585 | GEO
Sort   by:  
 Page size