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TranscriptomicsTranscription profiling of Drosophila Roo lines grown on lead containing food to investigate lead toxicity
75 Diosophilia Roo lines, recominant inbred lines, were raised to adulthood either on conventional diet or diet supplemented with lead acetate. Whole flies were used for RNA extraction. RNA was run on Dros Genome 2 arrays. Each line also genotyped for 88 markers; Control food consisted of standard c...
ORGANISM(S): Drosophila melanogaster 
2009-06-08 | E-GEOD-11695 | biostudies-arrayexpress
TranscriptomicsInfluence of Water Chemistry on Toxicogenomics of Chronic Lead Toxicity to the Fathead Minnow (Pimephales promelas)
Despite major successes in reducing the risks of lead (Pb) exposure over the past few decades, two issues of considerable importance remain unresolved: (1) how differences in water chemistry influence acute and chronic Pb toxicity, and (2) the elucidation of specific toxic mechanisms and modes of a...
ORGANISM(S): Pimephales promelas 
2008-04-06 | E-GEOD-8404 | biostudies-arrayexpress
TranscriptomicsMethodoligies for identifying lead toxicity
Quantifying impact of lead on cytokine production and gene expression in PBMCs Cells were treated with 10mkM lead acetate for one day, washed and grown in RPMI for the second day. Lead acetate was not added to matching control cells.
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-37567 | biostudies-arrayexpress
ProteomicsLead eliminating activity of Auricularia polytricha glycoprotein protects against lead acetate-induced hepatorenal toxicity in rats via positive immunoregulation pathway
Lead is a ubiquitous environmental and industrial pollutant. Its nonbiodegradable toxicity induces a plethora of human diseases. The current study was undertaken to purify a novel 252-kDa bioactive glycoprotein containing 1.15% carbohydrate from the edible fungus Auricularia polytricha with the abil...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-04 | PXD040493 | Pride
Rat Lead Liver 
ProteomicsThiol metabolic heterogeneity in immune cells causes distinct molecular mechanisms of toxicity upon chronic lead exposure
Lead pollution is global, billions of people are chronically exposed to lead. Biological thiols are nature sequesters of lead. Human immune system is highly vulnerable to lead, unfortunately the underlying mechanism remains unknown. Using mass cytometry and mass spectrometry, we systematically ident...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-10-30 | PXD057344 |
ProteomicsImpact of neonatal lead exposure on memory: A study highlighting the association between hippocampal synaptic proteome and cognitive decline in rats
Lead (Pb2+) is a heavy metal ubiquitously present in the environment, with unknown essential functions to sustain life. The detrimental effects of Pb2+ on health are known since ancient times, which is also well supported by scientific literature. Incidentally, Pb2+ toxicity is more severe in childr...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-10 | PXD034212 | Pride
Lead toxicity Proteomics Hippocampus Memory impairment 
ProteomicsAnalysis of Macleaya cordata leave under lead treatment
The objectives of this study were to investigate response and tolerance of Macleaya cordata to lead（Pb）toxicity based on comparative analysis of proteome.
ORGANISM(S): Macleaya Cordata 
2022-11-14 | PXD038143 |
TranscriptomicsInfluence of Water Chemistry on Toxicogenomics of Chronic Lead Toxicity to the Fathead Minnow (Pimephales promelas)
Despite major successes in reducing the risks of lead (Pb) exposure over the past few decades, two issues of considerable importance remain unresolved: (1) how differences in water chemistry influence acute and chronic Pb toxicity, and (2) the elucidation of specific toxic mechanisms and modes of ac...
ORGANISM(S): Pimephales promelas 
2008-04-07 | GSE8404 | GEO
TranscriptomicsMethodoligies for identifying lead toxicity
Quantifying impact of lead on cytokine production and gene expression in PBMCs
ORGANISM(S): Homo sapiens 
2012-06-01 | GSE37567 | GEO
GenomicsHomo sapiens
Methodoligies for identifying lead toxicity
PRJNA161869 | ENA
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