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MetabolomicsUntargeted metabolomics identifies a plasma sphingolipid-related signature associated with lifestyle intervention in prepubertal children with obesity

OBJECTIVE: Childhood obesity is a strong risk factor for adult obesity and metabolic diseases, including type 2 diabetes and cardiovascular disease. Early lifestyle intervention in children with obesity reduces future disease risk. The objective of this study is to identify metab...

2018-02-09 | MTBLS423 | MetaboLights
MetabolomicsSearching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory drug, ...
2021-02-08 | MTBLS873 | MetaboLights
UnknownA Three-Monoclonal Antibody Combination Potently Neutralizes BoNT/G Toxin in Mice.
Not available
S-EPMC10222606 | biostudies-literature
ProteomicsEnforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration
Alteration to endoplasmic reticulum (ER) proteostasis is observed on a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER proteostasis and cell function. The UPR is initiated...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD022554 | Pride
Xbp1 Huntington`s disease Atf6 Upr Parkinson`s disease Er stress Protein aggregation 
TranscriptomicsGene-expression profile in a series of non-Hodgkin lymphoma (NHL) patients
PIM serine/threonine kinases are overexpressed, translocated or amplified in multiple B-cell lymphoma types. We have explored the frequency and relevance of PIM expression in different B-cell lymphoma types, and investigated whether PIM inhibition could be a rational therapeutic approach. Increased ...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-32018 | biostudies-arrayexpress
UnknownDysfunctional adiposity index as a marker of adipose tissue morpho-functional abnormalities and metabolic disorders in apparently healthy subjects.
Not available
S-EPMC7971216 | biostudies-literature
UnknownBombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition.
Not available
S-EPMC2072049 | biostudies-literature
UnknownComplete Genome Sequences of Fish Pathogenic Weissella ceti Strains WS74 and WS105.
Not available
S-EPMC4200148 | biostudies-literature
UnknownWhole-Genome Sequence of Francisella noatunensis subsp. orientalis Strain FNO01 Isolated from Diseased Nile Tilapia in Brazil.
Not available
S-EPMC4722272 | biostudies-literature
UnknownA global reference for caesarean section rates (C-Model): a multicountry cross-sectional study.
Not available
S-EPMC4873961 | biostudies-literature
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