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ProteomicsLETR1 (LINC01197) RNA pull-down in human LECs followed by LC-MSMS
Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. There is ample evidence that distinct types of vasculature undergo tight transcriptional control to preserve their structure, identity, and functions. We determined, for the...
ORGANISM(S): Homo sapiens (Human) 
2020-12-21 | PXD018578 | Pride
Human Lesr2 Lc-msms Linc01197 Lncrna Lecs 
TranscriptomicsTranscriptional profiling of immortalized LECs (imLECs)
In contrast to the migration of leukocytes from blood vessels into tissues, and the involvement of adhesion molecules and chemokines in this process, the migration of leukocytes from the tissue into lymphatic vessels is much less well understood. This can, in part be explained by the fact that murin...
ORGANISM(S): Mus musculus 
2011-03-31 | E-GEOD-28234 | biostudies-arrayexpress
TranscriptomicsL1CAM overexpression in mouse lung endothelial cells (lECs)
In an attempt to elucidate the molecular mechanisms underlying the multiple roles of L1 in endothelium, we checked whether manipulating its expression affected the transcriptome of lECs. To this purpose, we compared the gene expression profiles of L1-overexpressing and control lECs by Affymetrix, wh...
ORGANISM(S): Mus musculus 
2014-10-21 | E-GEOD-45859 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver endothelial cells in cirrhotic rats
The study was performed in liver-endothelial cells (LECs) isolated from 6 adult male Wistar rats, undergoing a cirrhosis induction protocol as described previously by our group, and LECs isolated from 6 control Wistar rats, according to the criteria of the Investigation and Ethics Committee of the H...
ORGANISM(S): Rattus norvegicus 
2007-09-05 | E-GEOD-1843 | biostudies-arrayexpress
GenomicsTranscriptional profiling of melanoma-associated lymphatic endothelial cells (LECs)
Transcriptional profiling of melanoma-associated lymphatic endothelial cells (LECs)
PRJNA839387 | ENA
MetabolomicsMetabolomics revealed the influence of breast cancer on lymphatic endothelial cell metabolism, metabolic crosstalk, and lymphangiogenic signaling in co-culture

Breast cancer metastasis occurs via blood and lymphatic vessels. Breast cancer cells 'educate' lymphatic endothelial cells (LECs) to support tumor vascularization and growth. However, despite known metabolic alterations in breast cancer, it remains unclear how lymphatic endothelial cell metabolis...

2024-06-25 | MTBLS859 | MetaboLights
TranscriptomicsTranscriptional profiling of ex vivo isolated inflammed mouse lymphatic endothelial cells
Chemokines and adhesion molecules upregulated in lymphatic endothelial cells (LECs) during tissue inflammation are believed to enhance dendritic cell (DC) migration to draining lymph nodes (dLNs), but the in vivo control of this process is not well understood. By performing transcriptional profiling...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-26229 | biostudies-arrayexpress
TranscriptomicsChIP-chip study aimed at the identification of the repertoire of FOXC2 binding sites affected by the loss of FOXC2 phosphorylation in primary human lymphatic endothelial cells (LECs)
Chromatin immunoprecipitation microarray (ChIP-chip) study using anti-Myc (9E10) antibodies and primary human lymphatic endothelial cells (LECs) transduced with recombinant adenoviruses expressing wild type or phosphorylation-deficient Myc-tagged FOXC2.
ORGANISM(S): Homo sapiens 
2013-07-13 | E-MTAB-596 | biostudies-arrayexpress
no omics definedTranscription profiling of human blood and lymphatic endothelial cells (BECs and LECs) with and without culture in order to evaluate the artefact of cell culture on the level of the transcriptome
We compared human blood and lymphatic endothelial cells (BECs and LECs) with and without culture in order to evaluate the artefact of cell culture on the level of the transcriptome.
ORGANISM(S): Homo sapiens 
2006-09-13 | E-MEXP-455 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of melanoma-associated lymphatic endothelial cells (LECs)
Objective was to uncover the transcriptional changes occuring in melanoma-associated LECs relative to LECs of naïve skin. To investigate the transcriptional changes in LECs during tumor development, RNA was extracted from LECs sorted from naïve skin and BPC (Tyr::Cre-ER, BRafV600E) murine melanomas ...
ORGANISM(S): Mus musculus 
2023-01-20 | GSE203307 | GEO
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