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MetabolomicsGlycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...
2024-02-07 | MTBLS6847 | MetaboLights
UnknownClinical and Molecular Spectrum of Liposarcoma.
Not available
S-EPMC5759315 | biostudies-literature
UnknownAccurate FRET measurements within single diffusing biomolecules using alternating-laser excitation.
Not available
S-EPMC1282518 | biostudies-literature
UnknownAtrial fibrillation classification based on convolutional neural networks.
Not available
S-EPMC6819477 | biostudies-literature
UnknownThe application of infrared thermography technology in flap: A perspective from bibliometric and visual analysis.
Not available
S-EPMC10681462 | biostudies-literature
ProteomicsDDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the stalling of RNA...
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD051638 | Pride
Crl4csa Rna polymerase ii Dna damage Dda1 Transcription-coupled repair 
MetabolomicsLongitudinal Deep Multi-Omics Profiling in aCLN3Δex7/8Minipig Model Reveals Novel Biomarker Signatures for Batten Disease
Development of therapies for CLN3 Batten disease, a rare pediatric lysosomal storage disorder, has been hindered by the lack of etiological insights and translatable biomarkers to clinics. Here, we used a deep multi-omics approach to discover new biomarkers using longitudinal serum samples from a po...
2025-08-13 | MTBLS1107 | MetaboLights
UnknownA Combination of Oxo-M and 4-PPBP as a potential regenerative therapeutics for tendon injury.
Not available
S-EPMC6592164 | biostudies-literature
UnknownSafety and efficacy of pembrolizumab for advanced nonsmall cell lung cancer: before and during the COVID-19 pandemic.
Not available
S-EPMC9281358 | biostudies-literature
UnknownObservation of superoxide production during catalysis of Bacillus subtilis oxalate decarboxylase at pH 4.
Not available
S-EPMC4355160 | biostudies-literature
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