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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
ProteomicsPhosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantit...
ORGANISM(S): Plasmodium falciparum 
2017-09-22 | PXD002266 | Pride
Malaria Quantitation Signalling Phosphorylation Parasite Invasion Protein kinase g Tandem mass tags 
ProteomicsS. cerevisiae DDA orbitrap-based benchmark datasets. C4PR_LIV
In this study, label free peptide intensities from a well quantitatively characterised yeast cell lysate were acquired on two orbitrap mass spectrometers (LTQ-Velos and Q Exactive HF). Additionally, samples containing Universal Proteomics Standard and the Proteomics Dynamic range Standard (http://ww...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-08-09 | PXD003472 | Pride
Peptide ionization Hydrophobicity Benchmark dataset Coelution Peptide detectability 
MetabolomicsGlycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
Central carbon metabolism is highly conserved across microbial species, but can catalyze very different pathways depending on the organism and their ecological niche. Here, we study the dynamic reorganization of central metabolism after switches between the two major opposing pathway configurations ...
2022-01-11 | MTBLS3887 | MetaboLights
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
UnknownThe BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer.
Not available
S-EPMC5065110 | biostudies-literature
TranscriptomicsTranscription profiling of Xenopus laevis gastrula ventral and dorsal halves at NF stages 10 and 11.5 injected with noggin and dkk-1 plasmid
Studies of the Xenopus organizer have laid the foundation for our understanding of the conserved signaling pathways that pattern vertebrate embryos during gastrulation. Here, we use this wealth of knowledge as leverage in the design and analysis of a genomic visualization of organizer-related gene ...
ORGANISM(S): Xenopus laevis 
2007-10-05 | E-GEOD-3368 | biostudies-arrayexpress
GenomicsFOXM1 ChIP-seq in an OE33 cell line
Chromatin immunoprecipitation using anti-FOXM1 (Santa Cruz Biotechnology: sc- 502X) antibodies in an OE33 cell line
ORGANISM(S): Homo sapiens 
2015-12-14 | E-MTAB-4121 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of constitutive activation of Smoothened in the mouse uterus
In order to gain a better understanding of Ihh action during embryo implantation, we constitutively activated Smo in the murine uterus using the PRcre mouse model (PRcre/+SmoM2+; SmoM2). Female SmoM2 mice were infertile. They exhibited normal serum progesterone levels and normal ovulation, but ova ...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-17263 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating of paediatric malignancies and one for which no effective therapy exists. A major contributor to the failure of therapeutic trials is the assumption that biologic properties of brainstem tumours in children are identical to cereb...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-18828 | biostudies-arrayexpress
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