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ProteomicsOpen-Gate Mutants of the Mammalian Proteasome Show Enhanced Ubiquitin-Conjugate Degradation
When in the closed form, the axial substrate translocation channel of the proteasome core particle (CP) is topologically blocked by the convergent N-termini of subunits. To probe the role of channel gating in mammalian proteasomes, we have deleted the N-terminal tail of 3. The resulting 3N proteaso...
ORGANISM(S): Homo sapiens (Human) 
2016-03-01 | PXD003577 | Pride
Proteasome Proteomics Gate Tau Oxidative stress Aggregation 
UnknownRandomized, Placebo-Controlled, Phase III Trial of Yeast-Derived Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Versus Peptide Vaccination Versus GM-CSF Plus Peptide Vaccination Versus Placebo in Patients With No Evidence of Disease After Complete Surgical Resection of Locally Advanced and/or Stage IV Melanoma: A Trial of the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Group (E4697).
Not available
S-EPMC4669592 | biostudies-literature
UnknownCetuximab Plus Chemoradiotherapy for HIV-Associated Anal Carcinoma: A Phase II AIDS Malignancy Consortium Trial.
Not available
S-EPMC5455422 | biostudies-literature
UnknownAnatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.
Not available
S-EPMC5607351 | biostudies-literature
UnknownPegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047.
Not available
S-EPMC3530691 | biostudies-literature
UnknownExome sequencing in the clinical diagnosis of sporadic or familial cerebellar ataxia.
Not available
S-EPMC4324730 | biostudies-literature
ProteomicsIdentification of WT and mutant OSBPL2 interactors
Pathogenic OSBPL2 mutations led to almost identical truncated proteins, which formed cytoplasmic aggregates, we performed a proteomic analysis to understand the function of mutant OSBPL2 via the identification of its interactome.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD021514 | Pride
Proteomics Interactors Mutant protein 
UnknownOlder adults with newly diagnosed high-risk/secondary AML who achieved remission with CPX-351: phase 3 post hoc analyses.
Not available
S-EPMC7993093 | biostudies-literature
ProteomicsUntargeted proteomics enables ultra-rapid variant prioritization in mitochondrial and other rare diseases
Only half of individuals with suspected rare diseases receive a definitive genetic diagnosis following genomic testing. A genetic diagnosis allows access to appropriate patient care and reduces the number of potentially unnecessary interventions and related healthcare costs. Here, we demonstrate tha...
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD055473 | Pride
Human Fibroblasts Pbmcs Hek293t Orbitrap 
UnknownRandomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597.
Not available
S-EPMC3821010 | biostudies-literature
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